Detailed information NTG0646573

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LZT96_RS04345
• Genome accession: NZ_CP090941
• Coordinates: 936860..937906 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain HAF242
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 931860..942906

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LZT96_RS04320 (LZT96_04320)	-	933001..933537 (+)	537	WP_002494124.1	hypothetical protein	-
LZT96_RS04325 (LZT96_04325)	-	933688..934674 (-)	987	WP_002494125.1	aromatic acid exporter family protein	-
LZT96_RS04330 (LZT96_04330)	map	934848..935603 (+)	756	WP_002498662.1	type I methionyl aminopeptidase	-
LZT96_RS04335 (LZT96_04335)	-	935761..936147 (+)	387	WP_001830382.1	hypothetical protein	-
LZT96_RS04340 (LZT96_04340)	liaF	936162..936863 (+)	702	WP_002498661.1	cell wall-active antibiotics response protein LiaF	-
LZT96_RS04345 (LZT96_04345)	vraS	936860..937906 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
LZT96_RS04350 (LZT96_04350)	vraR	937896..938525 (+)	630	WP_002473914.1	two-component system response regulator VraR	Regulator
LZT96_RS04355 (LZT96_04355)	-	938582..939760 (-)	1179	WP_002498660.1	YihY/virulence factor BrkB family protein	-
LZT96_RS04360 (LZT96_04360)	-	940167..940451 (-)	285	WP_002473916.1	YtxH domain-containing protein	-
LZT96_RS04365 (LZT96_04365)	-	940459..940923 (-)	465	WP_002498659.1	low molecular weight protein-tyrosine-phosphatase	-
LZT96_RS04370 (LZT96_04370)	-	941064..941279 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
LZT96_RS04375 (LZT96_04375)	-	941281..942522 (+)	1242	WP_002498658.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=646573 LZT96_RS04345 WP_001830374.1 936860..937906(+) (vraS) [Staphylococcus epidermidis strain HAF242]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=646573 LZT96_RS04345 WP_001830374.1 936860..937906(+) (vraS) [Staphylococcus epidermidis strain HAF242]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACGGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ACATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCTAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCAGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTGTTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCATTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGCGACA
TTCAAATGGTACAAAAGTAACTGTAGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92