Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   KB228_RS03755 Genome accession   NZ_CP090912
Coordinates   818080..818796 (-) Length   238 a.a.
NCBI ID   WP_001829999.1    Uniprot ID   C0LF82
Organism   Staphylococcus epidermidis strain 44     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 813080..823796
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KB228_RS03740 (KB228_03740) - 814361..815314 (+) 954 WP_001830022.1 LacI family DNA-binding transcriptional regulator -
  KB228_RS03745 (KB228_03745) - 815574..817046 (+) 1473 WP_001830011.1 sucrose-6-phosphate hydrolase -
  KB228_RS03750 (KB228_03750) - 817053..818012 (+) 960 WP_002468351.1 carbohydrate kinase family protein -
  KB228_RS03755 (KB228_03755) agrA 818080..818796 (-) 717 WP_001829999.1 quorum-sensing response regulator AgrA Regulator
  KB228_RS03760 (KB228_03760) agrC 818813..820102 (-) 1290 WP_002495230.1 quorum-sensing sensor histidine kinase AgrC -
  KB228_RS03765 (KB228_03765) agrD 820127..820267 (-) 141 WP_002468352.1 cyclic lactone autoinducer peptide AgrD -
  KB228_RS03770 (KB228_03770) - 820273..820836 (-) 564 WP_002502970.1 accessory gene regulator AgrB -
  KB228_RS03775 (KB228_03775) hld 821153..821230 (+) 78 WP_002494082.1 delta-hemolysin -
  KB228_RS03780 (KB228_03780) - 821611..822396 (-) 786 WP_002469371.1 carbon-nitrogen family hydrolase -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27936.97 Da        Isoelectric Point: 5.6250

>NTDB_id=646403 KB228_RS03755 WP_001829999.1 818080..818796(-) (agrA) [Staphylococcus epidermidis strain 44]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=646403 KB228_RS03755 WP_001829999.1 818080..818796(-) (agrA) [Staphylococcus epidermidis strain 44]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCTTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAGCTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAAGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGATATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATTGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTAATAAACAGGCATAATATTGAATCTATTG
ACTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0LF82

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

87.815

100

0.878
  comE/comE2 Streptococcus gordonii strain NCTC7865

35.178

100

0.374
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

35.178

100

0.374