Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   L1A12_RS10545 Genome accession   NZ_CP090882
Coordinates   2057463..2058788 (-) Length   441 a.a.
NCBI ID   WP_015511364.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain CH2241     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2052463..2063788
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1A12_RS10695 - 2054147..2055750 (-) 1604 Protein_2048 YhgE/Pip domain-containing protein -
  L1A12_RS10525 (L1A12_10525) - 2055929..2056471 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  L1A12_RS10540 (L1A12_10540) comE 2056714..2057466 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  L1A12_RS10545 (L1A12_10545) comD/comD1 2057463..2058788 (-) 1326 WP_015511364.1 competence system sensor histidine kinase ComD Regulator
  L1A12_RS10550 (L1A12_10550) comC/comC1 2058809..2058934 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  L1A12_RS10560 (L1A12_10560) rlmH 2059217..2059696 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  L1A12_RS10565 (L1A12_10565) htrA 2059879..2061060 (+) 1182 WP_000681597.1 trypsin-like peptidase domain-containing protein Regulator
  L1A12_RS10570 (L1A12_10570) spo0J 2061118..2061876 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51187.66 Da        Isoelectric Point: 6.9339

>NTDB_id=645646 L1A12_RS10545 WP_015511364.1 2057463..2058788(-) (comD/comD1) [Streptococcus pneumoniae strain CH2241]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=645646 L1A12_RS10545 WP_015511364.1 2057463..2058788(-) (comD/comD1) [Streptococcus pneumoniae strain CH2241]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGCTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTGACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.866

100

0.989
  comD/comD1 Streptococcus pneumoniae D39

98.866

100

0.989
  comD/comD1 Streptococcus pneumoniae R6

98.866

100

0.989
  comD/comD2 Streptococcus pneumoniae TIGR4

96.599

100

0.966
  comD Streptococcus mitis SK321

92.744

100

0.927
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.468

85.261

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42