Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   LK450_RS02950 Genome accession   NZ_CP085939
Coordinates   594789..596135 (-) Length   448 a.a.
NCBI ID   WP_003024354.1    Uniprot ID   -
Organism   Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 589789..601135
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK450_RS02930 (LK450_02930) rpsT 590199..590450 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  LK450_RS02935 (LK450_02935) - 590514..591023 (+) 510 WP_018543463.1 DNA topology modulation protein -
  LK450_RS02940 (LK450_02940) - 591073..592686 (-) 1614 WP_003032194.1 M20/M25/M40 family metallo-hydrolase -
  LK450_RS02945 (LK450_02945) - 592863..594311 (+) 1449 WP_003032171.1 alpha-amylase -
  LK450_RS02950 (LK450_02950) ciaH 594789..596135 (-) 1347 WP_003024354.1 cell wall metabolism sensor histidine kinase WalK Regulator
  LK450_RS02955 (LK450_02955) ciaR 596125..596799 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  LK450_RS02960 (LK450_02960) - 597072..597530 (-) 459 WP_003032188.1 hypothetical protein -
  LK450_RS02965 (LK450_02965) - 597872..598615 (-) 744 WP_003032183.1 alpha/beta fold hydrolase -
  LK450_RS02970 (LK450_02970) - 599026..599274 (+) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  LK450_RS02975 (LK450_02975) - 599271..599567 (+) 297 WP_003024343.1 type II toxin-antitoxin system RelE/ParE family toxin -
  LK450_RS02980 (LK450_02980) - 599677..600432 (-) 756 WP_003031299.1 hypothetical protein -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 51038.78 Da        Isoelectric Point: 10.1380

>NTDB_id=621388 LK450_RS02950 WP_003024354.1 594789..596135(-) (ciaH) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE
PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=621388 LK450_RS02950 WP_003024354.1 594789..596135(-) (ciaH) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG
CCTAAAACCGATACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA
GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGAGTTAGTGTTAAACCTT
TGTTGGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCTGTTTTACAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAACATGAAAATGTTGACGACAAATCTGCTTAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTAATGACGATTCTGTTTGACAATGCTCT
GAAATATACAGATGAAGACGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTAAAGGTTTCAGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGGGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCCCTTAAAGGAACTATTACGGTGAAAGATAA
TAAGCCGAAAGGAACCATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.429

100

0.714
  ciaH Streptococcus pneumoniae D39

71.429

100

0.714
  ciaH Streptococcus pneumoniae R6

71.429

100

0.714
  ciaH Streptococcus pneumoniae TIGR4

71.429

100

0.714
  ciaH Streptococcus mutans UA159

56.009

98.438

0.551