Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SCR2_RS04765 Genome accession   NC_022245
Coordinates   953596..954942 (-) Length   448 a.a.
NCBI ID   WP_006267810.1    Uniprot ID   -
Organism   Streptococcus constellatus subsp. pharyngis C818     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 948596..959942
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCR2_RS04745 (SCR2_0935) rpsT 949067..949303 (+) 237 WP_006269392.1 30S ribosomal protein S20 -
  SCR2_RS04750 (SCR2_0936) - 949368..949877 (+) 510 WP_020997811.1 DNA topology modulation protein -
  SCR2_RS04755 (SCR2_0937) - 949925..951538 (-) 1614 Protein_932 M20/M25/M40 family metallo-hydrolase -
  SCR2_RS04760 (SCR2_0938) - 951716..953164 (+) 1449 WP_006267911.1 alpha-amylase -
  SCR2_RS04765 (SCR2_0939) ciaH 953596..954942 (-) 1347 WP_006267810.1 sensor histidine kinase Regulator
  SCR2_RS04770 (SCR2_0940) ciaR 954932..955606 (-) 675 WP_003068917.1 response regulator transcription factor Regulator
  SCR2_RS04775 (SCR2_0941) - 955870..956313 (-) 444 WP_020997812.1 hypothetical protein -
  SCR2_RS04780 (SCR2_0942) - 956641..957399 (-) 759 WP_020997813.1 alpha/beta hydrolase -
  SCR2_RS04785 (SCR2_0943) - 957862..958110 (+) 249 WP_003024345.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  SCR2_RS04790 (SCR2_0944) - 958107..958403 (+) 297 WP_006267547.1 type II toxin-antitoxin system RelE family toxin -
  SCR2_RS04795 (SCR2_0945) - 958511..959359 (-) 849 WP_020997815.1 hypothetical protein -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50852.68 Da        Isoelectric Point: 10.0709

>NTDB_id=61822 SCR2_RS04765 WP_006267810.1 953596..954942(-) (ciaH) [Streptococcus constellatus subsp. pharyngis C818]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLEQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDHIRQIQVKSNYGREETYRMILFEVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMEASESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKIFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGMIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=61822 SCR2_RS04765 WP_006267810.1 953596..954942(-) (ciaH) [Streptococcus constellatus subsp. pharyngis C818]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAACAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCACTTGCTCGAAAAGTAGGGCTAGAGCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGACAAAGAATTGACAGATAAACCAAATGTTAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAGCCGATTATTACAAGCAATAATTTCTTAGGGCTCAATAAACTTTCCTTTAATAGTAAGCAATTAGACCACA
TTCGTCAGATTCAAGTAAAAAGCAATTATGGTCGAGAAGAAACCTATCGAATGATTTTATTTGAGGTAAAACTGCCTAAT
TTGGAGACCAATGTCAAATACGCAGCGGTTTTTATCAATATCAGTCAATTGGAACAAACTAGTCAAAATCATGAACAGTT
GATTGTGGTGGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTTTATCTTGCACGGGTCAGTGTTAAACCTC
TTTTAGAAAGCATTCAAAAGCAAAAAAGTTTTGTCGAAAACGCTAGTCATGAGTTGCGTACACCTCTAGCTGTGTTGCAA
AATCGTTTGGAGACTTTATTTAGAAAGCCAGAAGCTACTATTATGGAAGCCAGTGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAATATGAAAATGTTGACGACAAATTTACTCAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACAACTTTCACCAACTATGAAATGGTTGCCGCAGAGAATGGGAAAATTTTCCGATTT
GACAATAGGATTCACCGCGTAATTAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGATGAAGATGGTATGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.205

100

0.712
  ciaH Streptococcus pneumoniae D39

71.205

100

0.712
  ciaH Streptococcus pneumoniae R6

71.205

100

0.712
  ciaH Streptococcus pneumoniae TIGR4

71.205

100

0.712
  ciaH Streptococcus mutans UA159

55.251

97.768

0.54

Multiple sequence alignment