Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SII_RS04445 Genome accession   NC_022237
Coordinates   884139..885485 (-) Length   448 a.a.
NCBI ID   WP_003072859.1    Uniprot ID   A0A3R9KNQ5
Organism   Streptococcus intermedius C270     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 879139..890485
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SII_RS04420 (SII_0870) - 879560..880153 (-) 594 WP_020998684.1 class I SAM-dependent methyltransferase -
  SII_RS04425 (SII_0871) coaA 880246..881166 (+) 921 WP_020998685.1 type I pantothenate kinase -
  SII_RS04430 (SII_0872) rpsT 881235..881471 (+) 237 WP_003072853.1 30S ribosomal protein S20 -
  SII_RS04435 (SII_0873) - 881536..882045 (+) 510 WP_020998687.1 DNA topology modulation protein -
  SII_RS04440 (SII_0874) - 882415..883863 (+) 1449 WP_020998688.1 alpha-amylase -
  SII_RS04445 (SII_0875) ciaH 884139..885485 (-) 1347 WP_003072859.1 sensor histidine kinase Regulator
  SII_RS04450 (SII_0876) ciaR 885475..886149 (-) 675 WP_003036714.1 response regulator transcription factor Regulator
  SII_RS04455 (SII_0877) - 886411..886854 (-) 444 WP_020998689.1 hypothetical protein -
  SII_RS04460 (SII_0878) - 887153..887893 (-) 741 WP_020998690.1 alpha/beta hydrolase -
  SII_RS04470 (SII_0880) rplS 888138..888485 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  SII_RS04475 (SII_0881) - 888635..889594 (-) 960 WP_003076829.1 ROK family glucokinase -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50910.65 Da        Isoelectric Point: 10.1689

>NTDB_id=61520 SII_RS04445 WP_003072859.1 884139..885485(-) (ciaH) [Streptococcus intermedius C270]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLEQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKSIITSNNFLGFNKLSFNSKQLDRIRQIQVKSNYGREETYRMVLFQVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDIEPNFFNTTFTNYEMVATENGKVFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTVFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=61520 SII_RS04445 WP_003072859.1 884139..885485(-) (ciaH) [Streptococcus intermedius C270]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACTTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAATAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCGCTTGCTCGAAAAGTAGGGCTAGAGCAAAAGTCAGAAAATGGAGAA
CCTAAAAGCGGAACAGCTGATAAAGAGCTGACAGATAAACCAAATGTGAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAATCAATTATTACAAGCAATAATTTTTTAGGGTTTAATAAACTTTCCTTTAATAGCAAGCAATTAGATCGTA
TTCGTCAAATTCAAGTAAAAAGCAATTATGGCCGAGAAGAAACCTATCGGATGGTTTTGTTTCAAGTGAAATTGCCTAAT
TTAGAAACCAATGTCAAATACGCAGCAGTTTTTATCAATATTAGCCAATTGGAACAAACTAGTCAAAACCATGAACAGTT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTCTATCTTGCGCGAGTAAGTGTCAAACCGC
TTTTGGAAAGTATTCAAAAACAAAAGAGCTTTGTCGAAAATGCTAGTCATGAATTACGCACACCTTTAGCCGTTTTGCAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCTACCATTATGGAATCGAGTGAAAGCATCGCTTCTAGTTTAGATGA
AGTGCGAAACATGAAAATGTTGACAACGAACTTACTTAATTTAGCACGGCGTGATGATGGGATTAAACCAGAGATTGGTG
ATATTGAACCCAATTTCTTTAATACGACCTTTACGAACTATGAAATGGTTGCCACAGAAAATGGAAAAGTTTTTCGATTT
GACAATAGGATTCACCGTGTGATAAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCTT
GAAATATACAGACGAAGACGGTGTGATTGAATTAACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCAGGGATTAGTACAGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGACAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACTATTACAGTGAAAGATAA
TAAACCGAAAGGGACTGTTTTTGAAGTAAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9KNQ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.312

100

0.703
  ciaH Streptococcus pneumoniae D39

70.312

100

0.703
  ciaH Streptococcus pneumoniae R6

70.312

100

0.703
  ciaH Streptococcus pneumoniae TIGR4

70.312

100

0.703
  ciaH Streptococcus mutans UA159

55.708

97.768

0.545

Multiple sequence alignment