Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   NP436_RS07275 Genome accession   NZ_CP101932
Coordinates   1383871..1385220 (+) Length   449 a.a.
NCBI ID   WP_033881739.1    Uniprot ID   -
Organism   Bacillus subtilis subsp. natto strain BGSC 27E1     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1378871..1390220
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NP436_RS07250 (NP436_07250) dppD 1379007..1380014 (-) 1008 WP_014479578.1 dipeptide ABC transporter ATP-binding subunit DppD -
  NP436_RS07255 (NP436_07255) dppC 1380019..1380981 (-) 963 WP_014479577.1 dipeptide ABC transporter permease DppC -
  NP436_RS07260 (NP436_07260) dppB 1380987..1381913 (-) 927 WP_003245446.1 dipeptide ABC transporter permease DppB -
  NP436_RS07265 (NP436_07265) dppA 1381930..1382754 (-) 825 WP_014479576.1 D-aminopeptidase DppA -
  NP436_RS07270 (NP436_07270) proG 1382884..1383702 (-) 819 WP_014479575.1 pyrroline-5-carboxylate reductase ProG -
  NP436_RS07275 (NP436_07275) htrA 1383871..1385220 (+) 1350 WP_033881739.1 serine protease HtrA Regulator
  NP436_RS07280 (NP436_07280) gtcC 1385720..1386691 (-) 972 WP_014479573.1 glycosyltransferase family 2 protein -
  NP436_RS07285 (NP436_07285) ykcB 1386703..1388853 (-) 2151 WP_014479572.1 glycosyltransferase family 39 protein -
  NP436_RS07290 (NP436_07290) - 1388866..1388961 (-) 96 Protein_1372 hypothetical protein -
  NP436_RS07295 (NP436_07295) mhqA 1389070..1390020 (-) 951 WP_014479571.1 ring-cleaving dioxygenase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 47728.87 Da        Isoelectric Point: 4.6021

>NTDB_id=613168 NP436_RS07275 WP_033881739.1 1383871..1385220(+) (htrA) [Bacillus subtilis subsp. natto strain BGSC 27E1]
MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRGFGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAK
QSSSQQQTQSVTATSTSSESKKSSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG
SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDDHVTKVANFGDSSDLRTGETVIA
IGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSINVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFA
IPSNDVKPIAEELLSKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKAEDIIIGLK
GKEIDTGSELRNILYKDAKIGETVEVKILRNGKEMTKKIKLDQKEEKTS

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=613168 NP436_RS07275 WP_033881739.1 1383871..1385220(+) (htrA) [Bacillus subtilis subsp. natto strain BGSC 27E1]
ATGGATAACTATCGTGATGAAAACAGAACGAAAGGTAATGAGAATGAGGTCTTTTTAACGAAAGAGAACGATCAGAGCGC
CTCCTACTCGGCCCGCAATGTCATTCATGATCAGGAGAAGAAAAAACGAGGATTCGGATGGTTCAGACCGTTGCTTGGCG
GAGTGATCGGCGGCAGTCTCGCCCTTGGCATTTACACGTTTACACCGCTTGGCGACCATGATTCTCAGGACACTGCAAAA
CAATCATCCAGCCAGCAGCAAACGCAATCTGTTACAGCAACAAGCACCTCCTCTGAATCTAAAAAAAGCTCAAGCAGCTC
ATCTGCATTCAAGAGCGAGGACTCTTCTAAAATCTCAGATATGGTAGAAGACCTTTCACCAGCGATTGTCGGTATTACAA
ATCTTCAGGCACAATCAAACAGCTCTTTGTTCGGCTCTAGTTCTTCTGATTCCAGCGAAGATACAGAAAGCGGTTCAGGG
TCAGGTGTCATTTTCAAAAAAGAGAATGGCAAGGCTTATATCATTACAAATAACCACGTCGTAGAAGGGGCATCATCACT
GAAGGTATCTTTATATGACGGCACTGAGGTTACTGCAAAGCTGGTAGGCAGTGACTCGTTAACTGATTTAGCCGTCCTCC
AAATCAGTGATGACCACGTCACAAAAGTGGCAAACTTCGGTGATTCATCTGATCTTAGAACAGGCGAGACCGTTATTGCG
ATTGGGGATCCGCTTGGAAAAGACCTGTCCCGCACAGTAACACAAGGAATTGTAAGCGGCGTGGACAGAACGGTTTCAAT
GTCTACATCAGCCGGCGAAACGAGCATTAACGTCATTCAGACAGACGCAGCAATTAATCCAGGTAACAGCGGCGGTCCTT
TGTTAAATACAGACGGCAAAATTGTCGGCATTAACAGTATGAAAATCAGTGAGGATGATGTTGAGGGCATCGGATTTGCC
ATTCCAAGCAATGACGTAAAACCGATTGCTGAAGAACTGCTGTCTAAAGGCCAAATTGAACGTCCATATATCGGTGTCAG
CATGCTTGATCTGGAACAAGTGCCGCAAAATTACCAAGAAGGCACACTCGGCCTGTTCGGCAGCCAGCTGAATAAAGGTG
TTTACATCCGTGAGGTCGCTTCAGGCTCTCCTGCTGAAAAGGCCGGATTAAAAGCGGAGGATATTATCATCGGCCTAAAA
GGTAAAGAAATTGATACAGGCAGTGAATTGCGCAATATCTTATATAAAGACGCAAAGATCGGTGAAACCGTTGAAGTGAA
AATTCTCCGAAACGGCAAAGAAATGACGAAAAAAATTAAACTTGATCAAAAAGAAGAGAAAACTTCGTAA

Domains

Predicted by InterProScan.

Trypsin-like peptidase domain (Trypsin_2)

(160-304)

PDZ domain (PDZ_2)

(342-441)

Peptidase family M50 (Peptidase_M50)

(366-448)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

40.796

89.532

0.365
  htrA Streptococcus pneumoniae D39

40.796

89.532

0.365
  htrA Streptococcus pneumoniae R6

40.796

89.532

0.365
  htrA Streptococcus pneumoniae TIGR4

40.796

89.532

0.365
  htrA Streptococcus mitis NCTC 12261

39.32

91.759

0.361