Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NML18_RS00185 Genome accession   NZ_CP101269
Coordinates   35748..36338 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain EC21Z-048     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 30748..41338
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NML18_RS00155 (NML18_00155) ysdE 31172..31246 (+) 75 WP_211180519.1 protein YsdE -
  NML18_RS00160 (NML18_00160) tisB 31509..31598 (-) 90 WP_000060506.1 type I toxin-antitoxin system toxin TisB -
  NML18_RS00165 (NML18_00165) - 31914..33134 (+) 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
  NML18_RS00170 (NML18_00175) ivbL 33487..33585 (+) 99 WP_001315912.1 ilvB operon leader peptide IvbL -
  NML18_RS00175 (NML18_00180) ilvB 33691..35379 (+) 1689 WP_000168480.1 acetolactate synthase large subunit -
  NML18_RS00180 (NML18_00185) ilvN 35383..35673 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  NML18_RS00185 (NML18_00190) letA 35748..36338 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  NML18_RS00190 (NML18_00195) uhpB 36338..37840 (+) 1503 WP_001295243.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  NML18_RS00195 (NML18_00200) uhpC 37850..39169 (+) 1320 WP_000936565.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  NML18_RS00200 (NML18_00205) uhpT 39307..40698 (+) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=609775 NML18_RS00185 WP_000633668.1 35748..36338(+) (letA) [Escherichia coli strain EC21Z-048]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=609775 NML18_RS00185 WP_000633668.1 35748..36338(+) (letA) [Escherichia coli strain EC21Z-048]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAACTGCTAAGCCAGCTGCCGAAAGGTATGGCGACAATAATGCTCTCTGTT
CATGACAGTCCGGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTCTCCAAACGCTGTAGCCCTGACGA
ACTGATTGCGGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGCGAACGGCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCTGCC
GAACTGGGCTTGTCGCCGAAAACGGTGCACGTCCATCGCGCCAACCTGATGGAAAAACTGGGTGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378