Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   NML24_RS08600 Genome accession   NZ_CP101233
Coordinates   1791082..1792914 (+) Length   610 a.a.
NCBI ID   WP_001283421.1    Uniprot ID   P0A8G1
Organism   Escherichia coli strain EC21Z-137     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1786082..1797914
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NML24_RS08565 (NML24_08555) dcyD 1786308..1787294 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  NML24_RS08570 (NML24_08560) tcyL 1787309..1787977 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  NML24_RS08575 (NML24_08565) tcyN 1787974..1788726 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  NML24_RS08580 (NML24_08570) sdiA 1788956..1789678 (+) 723 WP_001154273.1 transcriptional regulator SdiA -
  NML24_RS08585 (NML24_08575) yecF 1789746..1789970 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  NML24_RS08590 (NML24_08580) yecU 1789957..1790133 (-) 177 WP_000590344.1 protein YecU -
  NML24_RS25375 - 1790171..1790287 (-) 117 WP_001302039.1 hypothetical protein -
  NML24_RS08595 (NML24_08585) letA 1790429..1791085 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  NML24_RS08600 (NML24_08590) uvrC 1791082..1792914 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  NML24_RS08605 (NML24_08595) pgsA 1792971..1793519 (+) 549 WP_032278420.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  NML24_RS08625 (NML24_08615) yecA 1794169..1794834 (+) 666 WP_254841619.1 UPF0149 family protein YecA -
  NML24_RS08630 (NML24_08620) tyrP 1794896..1796107 (-) 1212 WP_000797573.1 tyrosine transporter TyrP -
  NML24_RS08635 (NML24_08625) yecH 1796299..1796538 (+) 240 WP_000377223.1 YecH family metal-binding protein -
  NML24_RS08640 (NML24_08630) ftnA 1796576..1797073 (-) 498 WP_000917208.1 non-heme ferritin -
  NML24_RS08645 (NML24_08635) yecR 1797244..1797567 (-) 324 WP_001237869.1 YecR-like lipofamily protein -

Sequence

Protein


Download         Length: 610 a.a.        Molecular weight: 68188.03 Da        Isoelectric Point: 9.3685

>NTDB_id=609336 NML24_RS08600 WP_001283421.1 1791082..1792914(+) (uvrC) [Escherichia coli strain EC21Z-137]
MSDQFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQQIDVTVTHTETEALLL
EHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYR
NRSRPCLQYQIGRCLGPCVEGLVSEEEYAQQVEYVRLFLSGKDDQVLTQLISRMETASQNLEFEEAARIRDQIQAVRRVT
EKQFVSNTGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELSEVVETFVGQFYLQGSQMRTLPGEILLD
FNLSDKTLLADSLSELAGRKINVQTKPRGDRARYLKLARTNAATALTSKLSQQSTVHQRLTALASVLKLPEVKRMECFDI
SHTMGEQTVASCVVFDANGPLRAEYRRYNITGITPGDDYAAMNQVLRRRYGKAIDDSKIPDVILIDGGKGQLAQAKNVFA
ELDVSWDKNHPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSSLET
IEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH

Nucleotide


Download         Length: 1833 bp        

>NTDB_id=609336 NML24_RS08600 WP_001283421.1 1791082..1792914(+) (uvrC) [Escherichia coli strain EC21Z-137]
GTGAGTGATCAGTTTGACGCAAAAGCGTTTTTAAAAACCGTAACCAGCCAGCCAGGCGTTTATCGCATGTACGATGCTGG
TGGTACGGTTATCTATGTCGGCAAAGCGAAAGACCTGAAAAAACGGCTTTCCAGCTATTTCCGTAGCAACCTCGCTTCGC
GCAAAACCGAAGCGCTGGTCGCCCAGATCCAGCAAATTGATGTAACGGTTACTCATACAGAAACCGAAGCGCTGTTGCTG
GAACACAACTACATCAAACTCTATCAGCCGCGTTACAACGTTTTACTACGCGATGATAAATCTTATCCCTTTATCTTCCT
GAGTGGCGATACCCATCCGCGTCTGGCGATGCATCGTGGTGCGAAGCATGCTAAAGGTGAATATTTCGGCCCGTTCCCGA
ATGGCTATGCCGTACGTGAAACACTGGCGCTACTGCAAAAGATTTTCCCCATTCGCCAGTGCGAAAACAGTGTTTATCGC
AATCGCTCGCGTCCGTGTCTGCAATATCAGATAGGACGTTGTCTGGGGCCGTGCGTTGAAGGACTGGTGAGTGAAGAAGA
ATACGCTCAGCAGGTCGAGTATGTGCGCCTGTTTTTGTCTGGCAAAGATGATCAGGTGCTTACGCAACTGATTAGCCGTA
TGGAAACTGCCAGCCAGAATCTGGAGTTTGAAGAAGCTGCACGTATTCGCGACCAAATTCAGGCGGTGCGACGCGTCACC
GAAAAACAGTTTGTTTCCAATACCGGCGACGACCTTGACGTTATTGGTGTGGCGTTCGATGCGGGCATGGCTTGTGTCCA
CGTATTGTTCATTCGTCAGGGCAAAGTGCTCGGCAGCCGCAGCTATTTCCCGAAAGTGCCTGGCGGTACGGAACTGAGCG
AGGTGGTGGAAACCTTCGTAGGTCAGTTCTATTTACAAGGCAGCCAGATGCGCACCTTACCGGGTGAGATCCTGCTCGAT
TTTAATCTTAGCGATAAAACGCTGCTCGCCGATTCCCTTTCAGAACTGGCGGGACGCAAGATTAATGTTCAAACCAAACC
TCGCGGCGATAGGGCGCGTTATCTGAAACTCGCGCGCACCAATGCGGCGACGGCCTTAACCAGCAAACTTTCGCAGCAAT
CTACCGTTCACCAGCGACTGACCGCGCTTGCCAGCGTGTTGAAATTGCCGGAAGTGAAGCGGATGGAGTGCTTTGACATC
AGCCATACCATGGGCGAACAAACCGTCGCTTCCTGTGTGGTGTTTGATGCTAACGGCCCGCTGCGTGCGGAGTATCGGCG
CTATAACATTACTGGCATCACGCCGGGCGATGATTATGCGGCGATGAATCAGGTGCTGCGTCGGCGTTATGGTAAAGCCA
TTGACGACAGTAAGATCCCGGATGTGATCCTTATCGACGGCGGCAAAGGCCAGCTTGCGCAGGCGAAAAATGTCTTCGCC
GAACTGGATGTCTCATGGGATAAAAATCATCCGCTGCTACTTGGCGTTGCCAAAGGAGCAGATCGTAAGGCTGGGCTGGA
AACGCTGTTCTTTGAGCCGGAAGGTGAGGGATTCAGTTTGCCGCCAGATTCTCCCGCGCTGCATGTTATCCAGCATATTC
GCGATGAATCACACGATCACGCGATTGGCGGGCACCGTAAAAAACGGGCGAAGGTCAAAAATACCAGTTCCCTGGAAACC
ATTGAAGGCGTCGGGCCAAAACGTCGGCAAATGTTGTTGAAATATATGGGCGGTTTGCAAGGTTTACGTAACGCCAGCGT
CGAGGAAATTGCAAAAGTGCCGGGTATTTCGCAAGGTCTGGCAGAAAAGATCTTCTGGTCGTTGAAACATTGA

Domains

Predicted by InterProScan.

UvrB/uvrC motif (UVR)

(205-237)

Helix-hairpin-helix domain (HHH_5)

(558-609)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-542)

GIY-YIG catalytic domain (GIY-YIG)

(18-93)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0A8G1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

37.891

99.508

0.377
  uvrC Streptococcus pneumoniae R6

37.562

99.508

0.374
  uvrC Streptococcus pneumoniae D39

37.562

99.508

0.374