Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NML24_RS08595 Genome accession   NZ_CP101233
Coordinates   1790429..1791085 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain EC21Z-137     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1785429..1796085
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NML24_RS08565 (NML24_08555) dcyD 1786308..1787294 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  NML24_RS08570 (NML24_08560) tcyL 1787309..1787977 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  NML24_RS08575 (NML24_08565) tcyN 1787974..1788726 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  NML24_RS08580 (NML24_08570) sdiA 1788956..1789678 (+) 723 WP_001154273.1 transcriptional regulator SdiA -
  NML24_RS08585 (NML24_08575) yecF 1789746..1789970 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  NML24_RS08590 (NML24_08580) yecU 1789957..1790133 (-) 177 WP_000590344.1 protein YecU -
  NML24_RS25375 - 1790171..1790287 (-) 117 WP_001302039.1 hypothetical protein -
  NML24_RS08595 (NML24_08585) letA 1790429..1791085 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  NML24_RS08600 (NML24_08590) uvrC 1791082..1792914 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  NML24_RS08605 (NML24_08595) pgsA 1792971..1793519 (+) 549 WP_032278420.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  NML24_RS08625 (NML24_08615) yecA 1794169..1794834 (+) 666 WP_254841619.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=609335 NML24_RS08595 WP_000611328.1 1790429..1791085(+) (letA) [Escherichia coli strain EC21Z-137]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=609335 NML24_RS08595 WP_000611328.1 1790429..1791085(+) (letA) [Escherichia coli strain EC21Z-137]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482