Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMD33_RS00190 Genome accession   NZ_CP100981
Coordinates   33781..34371 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain ET220     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 28781..39371
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMD33_RS00155 (NMD33_00150) yidF 28896..29393 (+) 498 WP_000148061.1 radical SAM protein -
  NMD33_RS00160 (NMD33_00155) emrD 29401..30585 (-) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -
  NMD33_RS00165 (NMD33_00160) ysdE 30667..30741 (+) 75 WP_211180519.1 protein YsdE -
  NMD33_RS00170 (NMD33_00165) tisB 30865..30954 (-) 90 WP_001054909.1 type I toxin-antitoxin system toxin TisB -
  NMD33_RS00175 (NMD33_00170) ivbL 31519..31617 (+) 99 WP_001300753.1 ilvB operon leader peptide IvbL -
  NMD33_RS00180 (NMD33_00175) ilvB 31723..33411 (+) 1689 WP_000168475.1 acetolactate synthase large subunit -
  NMD33_RS00185 (NMD33_00180) ilvN 33415..33705 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  NMD33_RS00190 (NMD33_00185) letA 33781..34371 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  NMD33_RS00195 (NMD33_00190) uhpB 34371..35873 (+) 1503 WP_172409460.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  NMD33_RS00200 (NMD33_00195) uhpC 35883..37202 (+) 1320 WP_000936566.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  NMD33_RS00205 (NMD33_00200) uhpT 37340..38731 (+) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=608144 NMD33_RS00190 WP_000633668.1 33781..34371(+) (letA) [Escherichia coli strain ET220]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=608144 NMD33_RS00190 WP_000633668.1 33781..34371(+) (letA) [Escherichia coli strain ET220]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACGATTATGCTCTCCGTT
CACGACAGTCCTGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTTTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378