Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMD38_RS00180 Genome accession   NZ_CP100962
Coordinates   32966..33556 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain ET358     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 27966..38556
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMD38_RS00145 (NMD38_00140) yidF 28083..28580 (+) 498 WP_000148061.1 radical SAM protein -
  NMD38_RS00150 (NMD38_00145) emrD 28588..29772 (-) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -
  NMD38_RS00155 (NMD38_00150) ysdE 29854..29928 (+) 75 WP_211180519.1 protein YsdE -
  NMD38_RS00160 (NMD38_00155) tisB 30052..30141 (-) 90 WP_000060506.1 type I toxin-antitoxin system toxin TisB -
  NMD38_RS00165 (NMD38_00160) ivbL 30705..30803 (+) 99 WP_001312198.1 ilvB operon leader peptide IvbL -
  NMD38_RS00170 (NMD38_00165) ilvB 30909..32597 (+) 1689 WP_021570996.1 acetolactate synthase large subunit -
  NMD38_RS00175 (NMD38_00170) ilvN 32601..32891 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  NMD38_RS00180 (NMD38_00175) letA 32966..33556 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  NMD38_RS00185 (NMD38_00180) uhpB 33556..35058 (+) 1503 WP_021570995.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  NMD38_RS00190 (NMD38_00185) uhpC 35068..36387 (+) 1320 WP_000936566.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  NMD38_RS00195 (NMD38_00190) uhpT 36525..37916 (+) 1392 WP_106486932.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=607822 NMD38_RS00180 WP_000633668.1 32966..33556(+) (letA) [Escherichia coli strain ET358]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=607822 NMD38_RS00180 WP_000633668.1 32966..33556(+) (letA) [Escherichia coli strain ET358]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGTTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACAATAATGCTCTCTGTT
CATGACAGTCCGGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCGCGCGGCTTTCTCTCCAAACGCTGTAGCCCTGACGA
ACTGATTGCGGCGGTGCATACGGTTGCTACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTGACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTAGA
ACTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378