Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMD46_RS00175 Genome accession   NZ_CP100936
Coordinates   30605..31195 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain ET650     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 25605..36195
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMD46_RS00140 (NMD46_00135) yidF 25721..26218 (+) 498 WP_000148063.1 radical SAM protein -
  NMD46_RS00145 (NMD46_00140) emrD 26226..27410 (-) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -
  NMD46_RS00150 (NMD46_00145) ysdE 27492..27566 (+) 75 WP_211180519.1 protein YsdE -
  NMD46_RS00155 (NMD46_00150) tisB 27690..27779 (-) 90 WP_000060506.1 type I toxin-antitoxin system toxin TisB -
  NMD46_RS00160 (NMD46_00155) ivbL 28344..28442 (+) 99 WP_001300753.1 ilvB operon leader peptide IvbL -
  NMD46_RS00165 (NMD46_00160) ilvB 28548..30236 (+) 1689 WP_032279167.1 acetolactate synthase large subunit -
  NMD46_RS00170 (NMD46_00165) ilvN 30240..30530 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  NMD46_RS00175 (NMD46_00170) letA 30605..31195 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  NMD46_RS00180 (NMD46_00175) uhpB 31195..32697 (+) 1503 WP_032279164.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  NMD46_RS00185 (NMD46_00180) uhpC 32707..34026 (+) 1320 WP_000936566.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  NMD46_RS00190 (NMD46_00185) uhpT 34164..35555 (+) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=607252 NMD46_RS00175 WP_000633668.1 30605..31195(+) (letA) [Escherichia coli strain ET650]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=607252 NMD46_RS00175 WP_000633668.1 30605..31195(+) (letA) [Escherichia coli strain ET650]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACGATTATGCTCTCCGTT
CACGACAGTCCTGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTTTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378