Detailed information NTG0600054

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: K6969_RS06830
• Genome accession: NZ_CP082205
• Coordinates: 1410243..1410914 (-)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain AKJ18
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1405243..1415914

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6969_RS06805 (K6969_06705)	-	1405389..1405979 (-)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-
K6969_RS06810 (K6969_06710)	coaA	1406088..1407008 (+)	921	WP_002935283.1	type I pantothenate kinase	-
K6969_RS06815 (K6969_06715)	rpsT	1407067..1407315 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
K6969_RS06820 (K6969_06720)	-	1407541..1408770 (-)	1230	WP_171942488.1	transglutaminase domain-containing protein	-
K6969_RS06825 (K6969_06725)	ciaH	1408871..1410250 (-)	1380	WP_029943182.1	sensor histidine kinase	Regulator
K6969_RS06830 (K6969_06730)	ciaR	1410243..1410914 (-)	672	WP_014637852.1	response regulator transcription factor	Regulator
K6969_RS06835 (K6969_06735)	-	1411056..1411634 (-)	579	WP_321537342.1	hypothetical protein	-
K6969_RS06840 (K6969_06740)	phoU	1411784..1412440 (-)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
K6969_RS06845 (K6969_06745)	pstB	1412469..1413227 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
K6969_RS06850 (K6969_06750)	pstB	1413239..1414042 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
K6969_RS06855 (K6969_06755)	pstA	1414067..1414954 (-)	888	WP_029177889.1	phosphate ABC transporter permease PstA	-
K6969_RS06860 (K6969_06760)	pstC	1414944..1415861 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=600054 K6969_RS06830 WP_014637852.1 1410243..1410914(-) (ciaR) [Streptococcus suis strain AKJ18]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=600054 K6969_RS06830 WP_014637852.1 1410243..1410914(-) (ciaR) [Streptococcus suis strain AKJ18]
ATGATTAAGATTTTGTTGGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTGACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTGCCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368