Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   NBY21_RS03975 Genome accession   NZ_CP098197
Coordinates   805092..805751 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain Z0117EC0062     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 800092..810751
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NBY21_RS03945 (NBY21_03945) - 800208..801155 (+) 948 WP_001305106.1 iron-siderophore ABC transporter substrate-binding protein -
  NBY21_RS03950 (NBY21_03950) - 801152..802039 (+) 888 WP_000614960.1 MurR/RpiR family transcriptional regulator -
  NBY21_RS03955 (NBY21_03955) ygiN 802084..802398 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  NBY21_RS03960 (NBY21_03960) mdaB 802429..803010 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  NBY21_RS03965 (NBY21_03965) ygiZ 803368..803700 (+) 333 WP_022646136.1 DUF2645 family protein -
  NBY21_RS03970 (NBY21_03970) qseC 803746..805095 (-) 1350 WP_022646135.1 quorum sensing histidine kinase QseC -
  NBY21_RS03975 (NBY21_03975) ciaR 805092..805751 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  NBY21_RS03980 (NBY21_03980) ygiW 805903..806295 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  NBY21_RS03985 (NBY21_03985) ygiV 806348..806830 (+) 483 WP_000183492.1 GyrI-like domain-containing protein -
  NBY21_RS03990 (NBY21_03990) ygiS 806939..808546 (+) 1608 WP_022646134.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=597729 NBY21_RS03975 WP_001221493.1 805092..805751(-) (ciaR) [Escherichia coli strain Z0117EC0062]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=597729 NBY21_RS03975 WP_001221493.1 805092..805751(-) (ciaR) [Escherichia coli strain Z0117EC0062]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365