NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	KZB15_RS02305	Genome accession	NZ_CP079922
Coordinates	471131..471868 (+)	Length	245 a.a.
NCBI ID	WP_001219139.1	Uniprot ID	Q9F2F6
Organism	Streptococcus pneumoniae strain R36A
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 466131..476868

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KZB15_RS02275 (KZB15_02290)	-	467463..467750 (-)	288	WP_000777760.1	hypothetical protein	-
KZB15_RS02280 (KZB15_02295)	-	467760..468170 (-)	411	WP_001278301.1	HIT family protein	-
KZB15_RS02285 (KZB15_02300)	pptA	468238..468969 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
KZB15_RS02290 (KZB15_02305)	-	468966..470015 (+)	1050	WP_000653770.1	ABC transporter permease	-
KZB15_RS02295 (KZB15_02310)	-	470183..470512 (-)	330	WP_000132569.1	hypothetical protein	-
KZB15_RS02300 (KZB15_02315)	-	470788..471126 (+)	339	WP_000682124.1	LytTR family DNA-binding domain-containing protein	-
KZB15_RS02305 (KZB15_02320)	comE/blpR	471131..471868 (+)	738	WP_001219139.1	response regulator transcription factor	Regulator
KZB15_RS02310 (KZB15_02325)	-	471882..473222 (+)	1341	WP_001017622.1	sensor histidine kinase	-
KZB15_RS02315 (KZB15_02330)	blpC	473264..473419 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
KZB15_RS02320 (KZB15_02335)	-	473476..474837 (-)	1362	Protein_465	bacteriocin secretion accessory protein	-
KZB15_RS02325 (KZB15_02340)	comA/nlmT	474848..476524 (-)	1677	WP_306423909.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28814.94 Da Isoelectric Point: 6.0454

                                >NTDB_id=590100 KZB15_RS02305 WP_001219139.1 471131..471868(+) (comE/blpR) [Streptococcus pneumoniae strain R36A]

MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD

PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY

LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA

INNLH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=590100 KZB15_RS02305 WP_001219139.1 471131..471868(+) (comE/blpR) [Streptococcus pneumoniae strain R36A]

ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA

TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC

AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC

CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA

CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA

GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT

CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA

GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA

AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT

ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q9F2F6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384

Detailed information NTG0590100