Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   MYL23_RS00160 Genome accession   NZ_CP095830
Coordinates   29100..29690 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain EC12     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 24100..34690
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MYL23_RS00125 (MYL23_00120) yidF 24220..24717 (+) 498 WP_000148034.1 radical SAM protein -
  MYL23_RS00130 (MYL23_00125) emrD 24725..25909 (-) 1185 WP_001696327.1 multidrug efflux MFS transporter EmrD -
  MYL23_RS00135 (MYL23_00130) ysdE 25991..26065 (+) 75 WP_211180519.1 protein YsdE -
  MYL23_RS00140 (MYL23_00135) tisB 26189..26278 (-) 90 WP_000060506.1 type I toxin-antitoxin system toxin TisB -
  MYL23_RS00145 (MYL23_00140) ivbL 26842..26940 (+) 99 WP_001312198.1 ilvB operon leader peptide IvbL -
  MYL23_RS00150 (MYL23_00145) ilvB 27045..28733 (+) 1689 WP_000168476.1 acetolactate synthase large subunit -
  MYL23_RS00155 (MYL23_00150) ilvN 28737..29027 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  MYL23_RS00160 (MYL23_00155) letA 29100..29690 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  MYL23_RS00165 (MYL23_00160) uhpB 29690..31192 (+) 1503 WP_001318135.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  MYL23_RS00170 (MYL23_00165) uhpC 31202..32521 (+) 1320 WP_001696326.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  MYL23_RS00175 (MYL23_00170) uhpT 32777..34168 (+) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=585091 MYL23_RS00160 WP_000633668.1 29100..29690(+) (letA) [Escherichia coli strain EC12]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=585091 MYL23_RS00160 WP_000633668.1 29100..29690(+) (letA) [Escherichia coli strain EC12]
ATGATCACCGTTGCCCTTATAGACGATCACCTTATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCTGATATCTCCGGTCTGGAGCTTCTAAGCCAGCTGCCGAAAGGCATGGCGACAATTATGCTCTCCGTT
CACGACAGTCCGGCGCTGGTTGAGCAGGCGCTTAACGCCGGGGCGCGCGGCTTTCTCTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACTGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GCCAGGACCCGCTAACCAAACGCGAACGCCAGGTGGCAGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTTGA
ACTGGCGCGCCGTATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378