Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MYL38_RS21575 Genome accession   NZ_CP095820
Coordinates   4405634..4406293 (+) Length   219 a.a.
NCBI ID   WP_001221478.1    Uniprot ID   B7UIT0
Organism   Escherichia coli strain Jnd12     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4400634..4411293
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MYL38_RS21560 (MYL38_21480) ygiS 4402839..4404446 (-) 1608 WP_000288665.1 ABC transporter substrate-binding protein -
  MYL38_RS21565 (MYL38_21485) ygiV 4404555..4405037 (-) 483 WP_000183493.1 GyrI-like domain-containing protein -
  MYL38_RS21570 (MYL38_21490) ygiW 4405090..4405482 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  MYL38_RS21575 (MYL38_21495) ciaR 4405634..4406293 (+) 660 WP_001221478.1 quorum sensing response regulator transcription factor QseB Regulator
  MYL38_RS21580 (MYL38_21500) qseC 4406290..4407639 (+) 1350 WP_063121428.1 quorum sensing histidine kinase QseC -
  MYL38_RS21585 (MYL38_21505) mdaB 4407749..4408330 (+) 582 WP_000065421.1 NADPH:quinone oxidoreductase MdaB -
  MYL38_RS21590 (MYL38_21510) ygiN 4408361..4408675 (+) 315 WP_000633738.1 putative quinol monooxygenase -
  MYL38_RS21595 (MYL38_21515) - 4408720..4409607 (-) 888 WP_000614959.1 MurR/RpiR family transcriptional regulator -
  MYL38_RS21600 (MYL38_21520) - 4409604..4410551 (-) 948 WP_001318046.1 iron-siderophore ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24701.65 Da        Isoelectric Point: 6.9850

>NTDB_id=584991 MYL38_RS21575 WP_001221478.1 4405634..4406293(+) (ciaR) [Escherichia coli strain Jnd12]
MRILLIEDDMLIGDGIKTGLSKMGFSIDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=584991 MYL38_RS21575 WP_001221478.1 4405634..4406293(+) (ciaR) [Escherichia coli strain Jnd12]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCAT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7UIT0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365