Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   KU535_RS12890 Genome accession   NZ_CP077915
Coordinates   2648305..2648934 (+) Length   209 a.a.
NCBI ID   WP_000153536.1    Uniprot ID   A0A481NSD5
Organism   Staphylococcus aureus strain 282     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2643305..2653934
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KU535_RS12865 (KU535_12800) - 2643681..2644667 (-) 987 WP_000999713.1 FUSC family protein -
  KU535_RS12870 (KU535_12805) map 2645198..2645956 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  KU535_RS12875 (KU535_12810) - 2646173..2646559 (+) 387 WP_001110179.1 hypothetical protein -
  KU535_RS12880 (KU535_12815) liaF 2646574..2647275 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  KU535_RS12885 (KU535_12820) vraS 2647272..2648315 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  KU535_RS12890 (KU535_12825) vraR 2648305..2648934 (+) 630 WP_000153536.1 two-component system response regulator VraR Regulator
  KU535_RS12895 (KU535_12830) - 2649046..2650263 (-) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  KU535_RS12900 (KU535_12835) - 2650541..2650816 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  KU535_RS12905 (KU535_12840) - 2650823..2651287 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  KU535_RS12910 (KU535_12845) - 2651434..2651634 (+) 201 WP_000180460.1 DUF1128 family protein -
  KU535_RS12915 (KU535_12850) - 2651637..2652893 (+) 1257 WP_072419726.1 aminopeptidase -
  KU535_RS12920 (KU535_12855) - 2652983..2653513 (+) 531 WP_000184383.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23490.21 Da        Isoelectric Point: 5.1703

>NTDB_id=584974 KU535_RS12890 WP_000153536.1 2648305..2648934(+) (vraR) [Staphylococcus aureus strain 282]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSSGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=584974 KU535_RS12890 WP_000153536.1 2648305..2648934(+) (vraR) [Staphylococcus aureus strain 282]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGCGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSD5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373