Detailed information NTG0584973

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU535_RS12885
• Genome accession: NZ_CP077915
• Coordinates: 2647272..2648315 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 282
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2642272..2653315

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU535_RS12855 (KU535_12790)	-	2642639..2642749 (+)	111	WP_001790257.1	hypothetical protein	-
KU535_RS12860 (KU535_12795)	-	2642778..2643191 (+)	414	WP_001566709.1	hypothetical protein	-
KU535_RS12865 (KU535_12800)	-	2643681..2644667 (-)	987	WP_000999713.1	FUSC family protein	-
KU535_RS12870 (KU535_12805)	map	2645198..2645956 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU535_RS12875 (KU535_12810)	-	2646173..2646559 (+)	387	WP_001110179.1	hypothetical protein	-
KU535_RS12880 (KU535_12815)	liaF	2646574..2647275 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU535_RS12885 (KU535_12820)	vraS	2647272..2648315 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU535_RS12890 (KU535_12825)	vraR	2648305..2648934 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
KU535_RS12895 (KU535_12830)	-	2649046..2650263 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
KU535_RS12900 (KU535_12835)	-	2650541..2650816 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU535_RS12905 (KU535_12840)	-	2650823..2651287 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU535_RS12910 (KU535_12845)	-	2651434..2651634 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU535_RS12915 (KU535_12850)	-	2651637..2652893 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584973 KU535_RS12885 WP_001017131.1 2647272..2648315(+) (vraS) [Staphylococcus aureus strain 282]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584973 KU535_RS12885 WP_001017131.1 2647272..2648315(+) (vraS) [Staphylococcus aureus strain 282]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1