Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   MYL34_RS00180 Genome accession   NZ_CP095806
Coordinates   32074..32664 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain E371     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 27074..37664
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MYL34_RS00145 (MYL34_00140) yidF 27193..27690 (+) 498 WP_000148034.1 radical SAM protein -
  MYL34_RS00150 (MYL34_00145) emrD 27698..28882 (-) 1185 WP_001696327.1 multidrug efflux MFS transporter EmrD -
  MYL34_RS00155 (MYL34_00150) ysdE 28964..29038 (+) 75 WP_211180519.1 protein YsdE -
  MYL34_RS00160 (MYL34_00155) tisB 29162..29251 (-) 90 WP_000060506.1 type I toxin-antitoxin system toxin TisB -
  MYL34_RS00165 (MYL34_00160) ivbL 29815..29913 (+) 99 WP_001312198.1 ilvB operon leader peptide IvbL -
  MYL34_RS00170 (MYL34_00165) ilvB 30019..31707 (+) 1689 WP_000168476.1 acetolactate synthase large subunit -
  MYL34_RS00175 (MYL34_00170) ilvN 31711..32001 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  MYL34_RS00180 (MYL34_00175) letA 32074..32664 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  MYL34_RS00185 (MYL34_00180) uhpB 32664..34166 (+) 1503 WP_001318135.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  MYL34_RS00190 (MYL34_00185) uhpC 34176..35495 (+) 1320 WP_001696326.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  MYL34_RS00195 (MYL34_00190) uhpT 35751..37142 (+) 1392 WP_063091047.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=584752 MYL34_RS00180 WP_000633668.1 32074..32664(+) (letA) [Escherichia coli strain E371]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=584752 MYL34_RS00180 WP_000633668.1 32074..32664(+) (letA) [Escherichia coli strain E371]
ATGATCACCGTTGCCCTTATAGACGATCACCTTATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCTGATATCTCCGGTCTGGAGCTTCTAAGCCAGCTGCCGAAAGGCATGGCGACAATTATGCTCTCCGTT
CACGACAGTCCGGCGCTGGTTGAGCAGGCGCTTAACGCCGGGGCGCGCGGCTTTCTCTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACTGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GCCAGGACCCGCTAACCAAACGCGAACGCCAGGTGGCAGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTTGA
ACTGGCGCGCCGTATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378