Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MYL46_RS03700 Genome accession   NZ_CP095801
Coordinates   750803..751462 (-) Length   219 a.a.
NCBI ID   WP_001221478.1    Uniprot ID   B7UIT0
Organism   Escherichia coli strain E166     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 745803..756462
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MYL46_RS03675 (MYL46_03660) - 746545..747492 (+) 948 WP_001318046.1 iron-siderophore ABC transporter substrate-binding protein -
  MYL46_RS03680 (MYL46_03665) - 747489..748376 (+) 888 WP_000614959.1 MurR/RpiR family transcriptional regulator -
  MYL46_RS03685 (MYL46_03670) ygiN 748421..748735 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  MYL46_RS03690 (MYL46_03675) mdaB 748766..749347 (-) 582 WP_000065421.1 NADPH:quinone oxidoreductase MdaB -
  MYL46_RS03695 (MYL46_03680) qseC 749457..750806 (-) 1350 WP_000673349.1 quorum sensing histidine kinase QseC -
  MYL46_RS03700 (MYL46_03685) ciaR 750803..751462 (-) 660 WP_001221478.1 quorum sensing response regulator transcription factor QseB Regulator
  MYL46_RS03705 (MYL46_03690) ygiW 751614..752006 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  MYL46_RS03710 (MYL46_03695) ygiV 752059..752541 (+) 483 WP_000183493.1 GyrI-like domain-containing protein -
  MYL46_RS03715 (MYL46_03700) ygiS 752650..754257 (+) 1608 WP_000288665.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24701.65 Da        Isoelectric Point: 6.9850

>NTDB_id=584683 MYL46_RS03700 WP_001221478.1 750803..751462(-) (ciaR) [Escherichia coli strain E166]
MRILLIEDDMLIGDGIKTGLSKMGFSIDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=584683 MYL46_RS03700 WP_001221478.1 750803..751462(-) (ciaR) [Escherichia coli strain E166]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCAT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7UIT0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365