Detailed information NTG0584264

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU506_RS04725
• Genome accession: NZ_CP077868
• Coordinates: 980120..981163 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 366
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 975120..986163

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU506_RS04695 (KU506_04680)	-	975546..975656 (+)	111	WP_001790257.1	hypothetical protein	-
KU506_RS04700 (KU506_04685)	-	975685..976098 (+)	414	WP_025174552.1	hypothetical protein	-
KU506_RS04705 (KU506_04690)	-	976531..977517 (-)	987	WP_000999708.1	FUSC family protein	-
KU506_RS04710 (KU506_04695)	map	978046..978804 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU506_RS04715 (KU506_04700)	-	979021..979407 (+)	387	WP_001110179.1	hypothetical protein	-
KU506_RS04720 (KU506_04705)	liaF	979422..980123 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU506_RS04725 (KU506_04710)	vraS	980120..981163 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU506_RS04730 (KU506_04715)	vraR	981153..981782 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
KU506_RS04735 (KU506_04720)	-	981895..983112 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
KU506_RS04740 (KU506_04725)	-	983390..983665 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU506_RS04745 (KU506_04730)	-	983672..984136 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU506_RS04750 (KU506_04735)	-	984283..984483 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU506_RS04755 (KU506_04740)	-	984486..985742 (+)	1257	WP_078065149.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584264 KU506_RS04725 WP_001017131.1 980120..981163(+) (vraS) [Staphylococcus aureus strain 366]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584264 KU506_RS04725 WP_001017131.1 980120..981163(+) (vraS) [Staphylococcus aureus strain 366]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1