Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MU410_RS03735 Genome accession   NZ_CP095155
Coordinates   763000..763659 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain Iso00041     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 758000..768659
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MU410_RS03710 parE 758091..759983 (+) 1893 WP_000195292.1 DNA topoisomerase IV subunit B -
  MU410_RS03715 ygiN 760031..760345 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  MU410_RS03720 mdaB 760376..760957 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  MU410_RS03725 ygiZ 761276..761608 (+) 333 WP_023149630.1 DUF2645 family protein -
  MU410_RS03730 qseC 761654..763003 (-) 1350 WP_001401139.1 quorum sensing histidine kinase QseC -
  MU410_RS03735 ciaR 763000..763659 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  MU410_RS03740 ygiW 763811..764203 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  MU410_RS03745 ygiV 764256..764738 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  MU410_RS03750 mqsR 764943..765239 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  MU410_RS03755 mqsA 765241..765636 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  MU410_RS03760 ygiS 765769..767376 (+) 1608 WP_001295629.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=582579 MU410_RS03735 WP_001221493.1 763000..763659(-) (ciaR) [Escherichia coli strain Iso00041]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=582579 MU410_RS03735 WP_001221493.1 763000..763659(-) (ciaR) [Escherichia coli strain Iso00041]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365