Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MOO49_RS03510 Genome accession   NZ_CP093919
Coordinates   719593..720252 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain ST167     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 714593..725252
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MOO49_RS03485 parE 714684..716576 (+) 1893 WP_000195292.1 DNA topoisomerase IV subunit B -
  MOO49_RS03490 ygiN 716624..716938 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  MOO49_RS03495 mdaB 716969..717550 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  MOO49_RS03500 ygiZ 717869..718201 (+) 333 WP_000917685.1 DUF2645 family protein -
  MOO49_RS03505 qseC 718247..719596 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  MOO49_RS03510 ciaR 719593..720252 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  MOO49_RS03515 ygiW 720404..720796 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  MOO49_RS03520 ygiV 720849..721331 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  MOO49_RS03525 mqsR 721536..721832 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  MOO49_RS03530 mqsA 721834..722229 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  MOO49_RS03535 ygiS 722362..723969 (+) 1608 WP_087523553.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=572709 MOO49_RS03510 WP_001221493.1 719593..720252(-) (ciaR) [Escherichia coli strain ST167]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=572709 MOO49_RS03510 WP_001221493.1 719593..720252(-) (ciaR) [Escherichia coli strain ST167]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365