Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L7H17_RS10745 Genome accession   NZ_CP091836
Coordinates   2239163..2239822 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain SWYHX138.33gt     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2234163..2244822
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L7H17_RS10720 (L7H17_10720) ygiS 2235441..2237053 (-) 1613 Protein_2101 ABC transporter substrate-binding protein -
  L7H17_RS10725 (L7H17_10725) mqsA 2237186..2237581 (-) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  L7H17_RS10730 (L7H17_10730) mqsR 2237583..2237879 (-) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  L7H17_RS10735 (L7H17_10735) ygiV 2238084..2238566 (-) 483 WP_000183505.1 AraC family transcriptional regulator -
  L7H17_RS10740 (L7H17_10740) ygiW 2238619..2239011 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  L7H17_RS10745 (L7H17_10745) ciaR 2239163..2239822 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  L7H17_RS10750 (L7H17_10750) qseC 2239819..2241168 (+) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  L7H17_RS10755 (L7H17_10755) ygiZ 2241214..2241546 (-) 333 WP_000917684.1 DUF2645 family protein -
  L7H17_RS10760 (L7H17_10760) mdaB 2241865..2242446 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  L7H17_RS10765 (L7H17_10765) ygiN 2242477..2242791 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  L7H17_RS10770 (L7H17_10770) parE 2242839..2244731 (-) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=563638 L7H17_RS10745 WP_001221493.1 2239163..2239822(+) (ciaR) [Escherichia coli strain SWYHX138.33gt]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=563638 L7H17_RS10745 WP_001221493.1 2239163..2239822(+) (ciaR) [Escherichia coli strain SWYHX138.33gt]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365