Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L6L57_RS19180 Genome accession   NZ_CP091712
Coordinates   4021273..4021932 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain KFu014     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4016273..4026932
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6L57_RS19165 (L6L57_19165) ygiS 4018478..4020085 (-) 1608 WP_012311669.1 ABC transporter substrate-binding protein -
  L6L57_RS19170 (L6L57_19170) ygiV 4020194..4020676 (-) 483 WP_000183492.1 GyrI-like domain-containing protein -
  L6L57_RS19175 (L6L57_19175) ygiW 4020729..4021121 (-) 393 WP_012311800.1 OB fold stress tolerance protein YgiW -
  L6L57_RS19180 (L6L57_19180) ciaR 4021273..4021932 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  L6L57_RS19185 (L6L57_19185) qseC 4021929..4023278 (+) 1350 WP_000673347.1 quorum sensing histidine kinase QseC -
  L6L57_RS19190 (L6L57_19190) mdaB 4023388..4023969 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  L6L57_RS19195 (L6L57_19195) ygiN 4024000..4024314 (+) 315 WP_000633737.1 putative quinol monooxygenase -
  L6L57_RS19200 (L6L57_19200) - 4024359..4025246 (-) 888 WP_000614945.1 MurR/RpiR family transcriptional regulator -
  L6L57_RS19205 (L6L57_19205) - 4025243..4026190 (-) 948 WP_001305106.1 iron-siderophore ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=563310 L6L57_RS19180 WP_001221493.1 4021273..4021932(+) (ciaR) [Escherichia coli strain KFu014]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=563310 L6L57_RS19180 WP_001221493.1 4021273..4021932(+) (ciaR) [Escherichia coli strain KFu014]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTTTTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAGCCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365