Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L6L58_RS03575 Genome accession   NZ_CP091665
Coordinates   749599..750258 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain KOr019     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 744599..755258
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6L58_RS03550 (L6L58_03550) - 745341..746288 (+) 948 WP_001305106.1 iron-siderophore ABC transporter substrate-binding protein -
  L6L58_RS03555 (L6L58_03555) - 746285..747172 (+) 888 WP_033560346.1 MurR/RpiR family transcriptional regulator -
  L6L58_RS03560 (L6L58_03560) ygiN 747217..747531 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  L6L58_RS03565 (L6L58_03565) mdaB 747562..748143 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  L6L58_RS03570 (L6L58_03570) qseC 748253..749602 (-) 1350 WP_063624946.1 quorum sensing histidine kinase QseC -
  L6L58_RS03575 (L6L58_03575) ciaR 749599..750258 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  L6L58_RS03580 (L6L58_03580) ygiW 750410..750802 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  L6L58_RS03585 (L6L58_03585) ygiV 750855..751337 (+) 483 WP_000183492.1 GyrI-like domain-containing protein -
  L6L58_RS03590 (L6L58_03590) ygiS 751446..753053 (+) 1608 WP_001361224.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=562599 L6L58_RS03575 WP_001221493.1 749599..750258(-) (ciaR) [Escherichia coli strain KOr019]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=562599 L6L58_RS03575 WP_001221493.1 749599..750258(-) (ciaR) [Escherichia coli strain KOr019]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365