Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV54_RS11525 | Genome accession | NZ_CP073883 |
| Coordinates | 2362574..2363935 (+) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1287175 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2316899..2365560 | 2362574..2363935 | within | 0 |
Gene organization within MGE regions
Location: 2316899..2365560
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV54_RS11275 (KFV54_11285) | ccrA | 2316899..2318245 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV54_RS11280 (KFV54_11290) | ccrB | 2318266..2319894 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV54_RS11285 (KFV54_11295) | - | 2320365..2320715 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV54_RS11290 (KFV54_11300) | - | 2320800..2321111 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV54_RS11295 (KFV54_11305) | - | 2321130..2321651 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV54_RS11300 (KFV54_11310) | - | 2321653..2321859 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV54_RS11305 (KFV54_11315) | - | 2321852..2322175 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV54_RS11310 (KFV54_11320) | - | 2322370..2324262 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV54_RS11315 (KFV54_11325) | - | 2324269..2324646 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV54_RS11320 (KFV54_11330) | - | 2324884..2325249 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV54_RS11325 (KFV54_11335) | - | 2325242..2327656 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV54_RS11330 (KFV54_11340) | - | 2327737..2328353 (+) | 617 | Protein_2226 | CadD family cadmium resistance transporter | - |
| KFV54_RS11340 (KFV54_11350) | - | 2328627..2329265 (-) | 639 | Protein_2227 | sulfite exporter TauE/SafE family protein | - |
| KFV54_RS11345 (KFV54_11355) | cstR | 2329265..2329525 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV54_RS11350 (KFV54_11360) | - | 2329661..2330725 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV54_RS11355 (KFV54_11365) | cstB | 2330758..2332092 (+) | 1335 | Protein_2230 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV54_RS11360 (KFV54_11370) | - | 2332206..2333336 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| KFV54_RS11365 (KFV54_11375) | psm-mec | 2333670..2333738 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV54_RS11370 (KFV54_11380) | mecI | 2333823..2334194 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV54_RS11375 (KFV54_11385) | mecR1 | 2334194..2335951 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV54_RS11380 (KFV54_11390) | mecA | 2336048..2338057 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV54_RS11385 (KFV54_11395) | - | 2338103..2338531 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV54_RS11390 (KFV54_11400) | - | 2338628..2339371 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV54_RS11395 (KFV54_11405) | - | 2340168..2340557 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV54_RS11400 (KFV54_11410) | - | 2340593..2341267 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV54_RS11405 (KFV54_11415) | - | 2341712..2342968 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV54_RS11410 (KFV54_11420) | - | 2343411..2343956 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV54_RS11415 (KFV54_11425) | - | 2343974..2344183 (-) | 210 | Protein_2242 | heavy metal translocating P-type ATPase | - |
| KFV54_RS11420 (KFV54_11430) | - | 2344353..2345111 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV54_RS11425 (KFV54_11435) | - | 2345108..2345263 (-) | 156 | Protein_2244 | metal-sensing transcriptional repressor | - |
| KFV54_RS11435 (KFV54_11445) | - | 2345486..2345776 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV54_RS11440 (KFV54_11450) | - | 2345828..2346700 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV54_RS11445 (KFV54_11455) | - | 2346870..2347316 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV54_RS11450 (KFV54_11460) | - | 2347344..2347850 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV54_RS11455 (KFV54_11465) | - | 2347866..2348177 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV54_RS11460 (KFV54_11470) | - | 2348273..2348611 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV54_RS11465 (KFV54_11475) | - | 2348717..2350393 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV54_RS11470 (KFV54_11480) | - | 2350620..2352263 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV54_RS11475 (KFV54_11485) | - | 2352260..2352631 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV54_RS11480 (KFV54_11490) | - | 2352624..2353724 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV54_RS11485 (KFV54_11495) | - | 2353951..2355426 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV54_RS11490 (KFV54_11500) | - | 2355534..2356397 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV54_RS11495 (KFV54_11505) | - | 2356595..2356900 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV54_RS11500 (KFV54_11510) | - | 2358152..2360077 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV54_RS11505 (KFV54_11515) | - | 2360407..2360733 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV54_RS11510 (KFV54_11520) | - | 2360940..2361299 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV54_RS11515 (KFV54_11525) | - | 2361411..2361749 (-) | 339 | Protein_2261 | recombinase family protein | - |
| KFV54_RS11520 (KFV54_11530) | - | 2361758..2362387 (+) | 630 | Protein_2262 | hypothetical protein | - |
| KFV54_RS11525 (KFV54_11535) | ccrA | 2362574..2363935 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV54_RS11530 (KFV54_11540) | ccrB | 2363932..2365560 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561900 KFV54_RS11525 WP_001631036.1 2362574..2363935(+) (ccrA) [Staphylococcus epidermidis strain B1287175]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561900 KFV54_RS11525 WP_001631036.1 2362574..2363935(+) (ccrA) [Staphylococcus epidermidis strain B1287175]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |