Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L3Z43_RS18610 Genome accession   NZ_CP091427
Coordinates   3889955..3890614 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain 1000C-3     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3884955..3895614
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L3Z43_RS18585 ygiS 3886238..3887845 (-) 1608 WP_116290049.1 ABC transporter substrate-binding protein -
  L3Z43_RS18590 mqsA 3887978..3888373 (-) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  L3Z43_RS18595 mqsR 3888375..3888671 (-) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  L3Z43_RS18600 ygiV 3888876..3889358 (-) 483 WP_000183505.1 GyrI-like domain-containing protein -
  L3Z43_RS18605 ygiW 3889411..3889803 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  L3Z43_RS18610 ciaR 3889955..3890614 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  L3Z43_RS18615 qseC 3890611..3891960 (+) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  L3Z43_RS18620 ygiZ 3892006..3892338 (-) 333 WP_000917685.1 DUF2645 family protein -
  L3Z43_RS18625 mdaB 3892657..3893238 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  L3Z43_RS18630 ygiN 3893269..3893583 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  L3Z43_RS18635 parE 3893631..3895523 (-) 1893 WP_000195292.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=561339 L3Z43_RS18610 WP_001221493.1 3889955..3890614(+) (ciaR) [Escherichia coli strain 1000C-3]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=561339 L3Z43_RS18610 WP_001221493.1 3889955..3890614(+) (ciaR) [Escherichia coli strain 1000C-3]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365