Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | KFV40_RS12905 | Genome accession | NZ_CP073841 |
| Coordinates | 2649455..2651083 (+) | Length | 542 a.a. |
| NCBI ID | WP_001631035.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1264787 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602422..2651083 | 2649455..2651083 | within | 0 |
Gene organization within MGE regions
Location: 2602422..2651083
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV40_RS12650 (KFV40_12660) | ccrA | 2602422..2603768 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV40_RS12655 (KFV40_12665) | ccrB | 2603789..2605417 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV40_RS12660 (KFV40_12670) | - | 2605888..2606238 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV40_RS12665 (KFV40_12675) | - | 2606323..2606634 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV40_RS12670 (KFV40_12680) | - | 2606653..2607174 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV40_RS12675 (KFV40_12685) | - | 2607176..2607382 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV40_RS12680 (KFV40_12690) | - | 2607375..2607698 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV40_RS12685 (KFV40_12695) | - | 2607893..2609785 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV40_RS12690 (KFV40_12700) | - | 2609792..2610169 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV40_RS12695 (KFV40_12705) | - | 2610407..2610772 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV40_RS12700 (KFV40_12710) | - | 2610765..2613179 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV40_RS12705 (KFV40_12715) | - | 2613260..2613876 (+) | 617 | Protein_2484 | CadD family cadmium resistance transporter | - |
| KFV40_RS12715 (KFV40_12725) | - | 2614150..2614788 (-) | 639 | Protein_2485 | sulfite exporter TauE/SafE family protein | - |
| KFV40_RS12720 (KFV40_12730) | cstR | 2614788..2615048 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV40_RS12725 (KFV40_12735) | - | 2615184..2616248 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV40_RS12730 (KFV40_12740) | cstB | 2616281..2617615 (+) | 1335 | Protein_2488 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV40_RS12735 (KFV40_12745) | - | 2617729..2618838 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV40_RS12740 (KFV40_12750) | psm-mec | 2619193..2619261 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV40_RS12745 (KFV40_12755) | mecI | 2619346..2619717 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV40_RS12750 (KFV40_12760) | mecR1 | 2619717..2621474 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV40_RS12755 (KFV40_12765) | mecA | 2621571..2623580 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV40_RS12760 (KFV40_12770) | - | 2623626..2624054 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV40_RS12765 (KFV40_12775) | - | 2624151..2624894 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV40_RS12770 (KFV40_12780) | - | 2625691..2626080 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV40_RS12775 (KFV40_12785) | - | 2626116..2626790 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV40_RS12780 (KFV40_12790) | - | 2627235..2628491 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV40_RS12785 (KFV40_12795) | - | 2628934..2629479 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV40_RS12790 (KFV40_12800) | - | 2629497..2629706 (-) | 210 | Protein_2500 | heavy metal translocating P-type ATPase | - |
| KFV40_RS12795 (KFV40_12805) | - | 2629876..2630634 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV40_RS12800 (KFV40_12810) | - | 2630631..2630786 (-) | 156 | Protein_2502 | metal-sensing transcriptional repressor | - |
| KFV40_RS12810 (KFV40_12820) | - | 2631009..2631299 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV40_RS12815 (KFV40_12825) | - | 2631351..2632223 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV40_RS12820 (KFV40_12830) | - | 2632393..2632839 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV40_RS12825 (KFV40_12835) | - | 2632867..2633373 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV40_RS12830 (KFV40_12840) | - | 2633389..2633700 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV40_RS12835 (KFV40_12845) | - | 2633796..2634134 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV40_RS12840 (KFV40_12850) | - | 2634240..2635916 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV40_RS12845 (KFV40_12855) | - | 2636143..2637786 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV40_RS12850 (KFV40_12860) | - | 2637783..2638154 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV40_RS12855 (KFV40_12865) | - | 2638147..2639247 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV40_RS12860 (KFV40_12870) | - | 2639474..2640949 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV40_RS12865 (KFV40_12875) | - | 2641057..2641920 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV40_RS12870 (KFV40_12880) | - | 2642118..2642423 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV40_RS12875 (KFV40_12885) | - | 2643675..2645600 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV40_RS12880 (KFV40_12890) | - | 2645930..2646256 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV40_RS12885 (KFV40_12895) | - | 2646463..2646822 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV40_RS12890 (KFV40_12900) | - | 2646934..2647272 (-) | 339 | Protein_2519 | recombinase family protein | - |
| KFV40_RS12895 (KFV40_12905) | - | 2647281..2647910 (+) | 630 | Protein_2520 | hypothetical protein | - |
| KFV40_RS12900 (KFV40_12910) | ccrA | 2648097..2649458 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV40_RS12905 (KFV40_12915) | ccrB | 2649455..2651083 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62474.71 Da Isoelectric Point: 9.6103
>NTDB_id=561301 KFV40_RS12905 WP_001631035.1 2649455..2651083(+) (ccrB) [Staphylococcus epidermidis strain B1264787]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
Nucleotide
Download Length: 1629 bp
>NTDB_id=561301 KFV40_RS12905 WP_001631035.1 2649455..2651083(+) (ccrB) [Staphylococcus epidermidis strain B1264787]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
72.694 |
100 |
0.727 |