Detailed information NTG0056004

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: SCSC_RS08260
• Genome accession: NZ_AP014647
• Coordinates: 1684706..1685023 (-)
• Length: 105 a.a.
• NCBI ID: WP_006269985.1
• Uniprot ID: A0A380L4M2
• Organism: Streptococcus constellatus subsp. constellatus strain CCUG 24889
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1679706..1690023

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCSC_RS08230 (SCSC_1694)	-	1681041..1682240 (-)	1200	WP_006269979.1	acetate kinase	-
SCSC_RS08235 (SCSC_1695)	comGH	1682287..1683240 (-)	954	WP_006269998.1	class I SAM-dependent methyltransferase	Machinery gene
SCSC_RS08240 (SCSC_1696)	comGG/cglG	1683325..1683651 (-)	327	WP_003070783.1	competence type IV pilus minor pilin ComGG	Machinery gene
SCSC_RS08245 (SCSC_1697)	comGF/cglF	1683632..1684069 (-)	438	WP_006270001.1	competence type IV pilus minor pilin ComGF	Machinery gene
SCSC_RS08250 (SCSC_1698)	comGE/cglE	1684053..1684346 (-)	294	WP_006269989.1	competence type IV pilus minor pilin ComGE	Machinery gene
SCSC_RS08255 (SCSC_1699)	comGD	1684318..1684716 (-)	399	WP_006269995.1	competence type IV pilus minor pilin ComGD	Machinery gene
SCSC_RS08260 (SCSC_1700)	comGC	1684706..1685023 (-)	318	WP_006269985.1	competence type IV pilus major pilin ComGC	Machinery gene
SCSC_RS08265 (SCSC_1701)	comGB	1685020..1686042 (-)	1023	WP_037565861.1	competence type IV pilus assembly protein ComGB	Machinery gene
SCSC_RS08270 (SCSC_1702)	comGA	1685984..1686925 (-)	942	WP_006269992.1	competence type IV pilus ATPase ComGA	Machinery gene
SCSC_RS08275 (SCSC_1703)	-	1686995..1687360 (-)	366	WP_006269973.1	DUF1033 family protein	-
SCSC_RS08280 (SCSC_1704)	glnA	1687548..1688894 (-)	1347	WP_006269977.1	type I glutamate--ammonia ligase	-
SCSC_RS08285 (SCSC_1705)	-	1688933..1689292 (-)	360	WP_003070793.1	MerR family transcriptional regulator	-
SCSC_RS08290 (SCSC_1706)	-	1689369..1689899 (-)	531	WP_006269975.1	aromatic acid exporter family protein	-

Sequence

Protein

• Length: 105 a.a.
• Molecular weight: 11650.77 Da
• Isoelectric Point: 10.1006

>NTDB_id=56004 SCSC_RS08260 WP_006269985.1 1684706..1685023(-) (comGC) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MKKIKNIKVKAFTLVEMLVVLLIISVLMLLFVPNLTKQKEAVTEKGNAAVVKVVESQAELFEVNHTNEKATLSKLVSEGT
ITDKQAASYKAYYAKHTKEARTVAD

Nucleotide

• Length: 318 bp

>NTDB_id=56004 SCSC_RS08260 WP_006269985.1 1684706..1685023(-) (comGC) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGAAAAAAATTAAAAATATAAAGGTAAAAGCTTTCACTTTGGTGGAAATGTTAGTGGTGCTTCTAATCATCAGTGTTTT
GATGCTTTTGTTTGTTCCGAATTTGACCAAACAAAAAGAAGCTGTAACGGAAAAAGGAAATGCAGCTGTTGTGAAGGTTG
TCGAAAGTCAGGCAGAGCTTTTTGAAGTGAATCACACTAATGAAAAAGCGACGCTTTCAAAATTAGTCAGTGAAGGAACT
ATTACAGACAAGCAAGCAGCATCATACAAGGCTTATTATGCAAAACATACAAAAGAAGCTCGCACAGTTGCAGATTAA

Domains

Predicted by InterProScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (8-30)

3D structure

• AlphaFold DB: A0A380L4M2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC	Streptococcus gordonii str. Challis substr. CH1	72.381	100	0.724
comGC	Streptococcus mutans UA140	68.571	100	0.686
comGC	Streptococcus mutans UA159	68.571	100	0.686
comGC/cglC	Streptococcus mitis NCTC 12261	69.608	97.143	0.676
comGC/cglC	Streptococcus mitis SK321	68.627	97.143	0.667
comGC/cglC	Streptococcus pneumoniae Rx1	66.667	97.143	0.648
comGC/cglC	Streptococcus pneumoniae D39	66.667	97.143	0.648
comGC/cglC	Streptococcus pneumoniae TIGR4	66.667	97.143	0.648
comGC/cglC	Streptococcus pneumoniae R6	66.667	97.143	0.648
comGC	Lactococcus lactis subsp. cremoris KW2	55.769	99.048	0.552
comGC	Streptococcus suis isolate S10	64.045	84.762	0.543