Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L1P12_RS03785 Genome accession   NZ_CP091026
Coordinates   782788..783447 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain STEC383     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 777788..788447
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1P12_RS03760 parE 777879..779771 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  L1P12_RS03765 ygiN 779819..780133 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  L1P12_RS03770 mdaB 780164..780745 (-) 582 WP_235387432.1 NADPH:quinone oxidoreductase MdaB -
  L1P12_RS03775 ygiZ 781064..781396 (+) 333 WP_000917684.1 DUF2645 family protein -
  L1P12_RS03780 qseC 781442..782791 (-) 1350 WP_096111143.1 quorum sensing histidine kinase QseC -
  L1P12_RS03785 ciaR 782788..783447 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  L1P12_RS03790 ygiW 783599..783991 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  L1P12_RS03795 ygiV 784044..784526 (+) 483 WP_000183505.1 AraC family transcriptional regulator -
  L1P12_RS03800 mqsR 784731..785027 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  L1P12_RS03805 mqsA 785029..785424 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  L1P12_RS03810 ygiS 785557..787164 (+) 1608 WP_001295629.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=557689 L1P12_RS03785 WP_001221493.1 782788..783447(-) (ciaR) [Escherichia coli strain STEC383]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=557689 L1P12_RS03785 WP_001221493.1 782788..783447(-) (ciaR) [Escherichia coli strain STEC383]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365