Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L1O93_RS03620 Genome accession   NZ_CP091022
Coordinates   755983..756642 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain STEC276     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 750983..761642
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1O93_RS03595 parE 751074..752966 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  L1O93_RS03600 ygiN 753014..753328 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  L1O93_RS03605 mdaB 753359..753940 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  L1O93_RS03610 ygiZ 754259..754591 (+) 333 WP_000917684.1 DUF2645 family protein -
  L1O93_RS03615 qseC 754637..755986 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  L1O93_RS03620 ciaR 755983..756642 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  L1O93_RS03625 ygiW 756794..757186 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  L1O93_RS03630 - 757239..757340 (+) 102 Protein_714 AraC family transcriptional regulator -
  L1O93_RS03635 - 757347..758498 (-) 1152 WP_001254876.1 IS30-like element IS30 family transposase -
  L1O93_RS03640 - 758558..758944 (+) 387 Protein_716 GyrI-like domain-containing protein -
  L1O93_RS03645 mqsR 759149..759445 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  L1O93_RS03650 mqsA 759447..759842 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  L1O93_RS03655 ygiS 759975..761582 (+) 1608 WP_001295629.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=557527 L1O93_RS03620 WP_001221493.1 755983..756642(-) (ciaR) [Escherichia coli strain STEC276]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=557527 L1O93_RS03620 WP_001221493.1 755983..756642(-) (ciaR) [Escherichia coli strain STEC276]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365