Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   LZG50_RS03645 Genome accession   NZ_CP090611
Coordinates   730347..731006 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli isolate DCE7     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 725347..736006
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LZG50_RS03620 (LZG50_03620) - 726089..727036 (+) 948 WP_096840938.1 iron-siderophore ABC transporter substrate-binding protein -
  LZG50_RS03625 (LZG50_03625) - 727033..727920 (+) 888 WP_000614945.1 MurR/RpiR family transcriptional regulator -
  LZG50_RS03630 (LZG50_03630) ygiN 727965..728279 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  LZG50_RS03635 (LZG50_03635) mdaB 728310..728891 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  LZG50_RS03640 (LZG50_03640) qseC 729001..730350 (-) 1350 WP_000673384.1 quorum sensing histidine kinase QseC -
  LZG50_RS03645 (LZG50_03645) ciaR 730347..731006 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  LZG50_RS03650 (LZG50_03650) ygiW 731158..731550 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  LZG50_RS03655 (LZG50_03655) ygiV 731603..732085 (+) 483 WP_000183493.1 AraC family transcriptional regulator -
  LZG50_RS03660 (LZG50_03660) ygiS 732194..733801 (+) 1608 WP_096891035.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=555084 LZG50_RS03645 WP_001221493.1 730347..731006(-) (ciaR) [Escherichia coli isolate DCE7]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=555084 LZG50_RS03645 WP_001221493.1 730347..731006(-) (ciaR) [Escherichia coli isolate DCE7]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAGTGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACTGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGCCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365