Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   J4Q32_RS04745 Genome accession   NZ_CP071916
Coordinates   916067..917416 (+) Length   449 a.a.
NCBI ID   WP_233923009.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 19A-19087     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 911067..922416
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J4Q32_RS04725 (J4Q32_04720) coaB 911222..911911 (-) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  J4Q32_RS04730 (J4Q32_04725) - 912141..913811 (+) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  J4Q32_RS04735 (J4Q32_04730) mutY 914140..915315 (+) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  J4Q32_RS04740 (J4Q32_04735) micA 915370..916074 (+) 705 WP_000722076.1 response regulator YycF Regulator
  J4Q32_RS04745 (J4Q32_04740) micB 916067..917416 (+) 1350 WP_233923009.1 cell wall metabolism sensor histidine kinase VicK Regulator
  J4Q32_RS04750 (J4Q32_04745) vicX 917418..918227 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  J4Q32_RS04755 (J4Q32_04750) relB 918318..918560 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  J4Q32_RS04760 (J4Q32_04755) - 918562..918816 (+) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  J4Q32_RS04765 (J4Q32_04760) - 918863..919636 (+) 774 WP_000731129.1 potassium channel family protein -
  J4Q32_RS04770 (J4Q32_04765) - 919952..921298 (-) 1347 WP_001814919.1 IS1380-like element ISSpn5 family transposase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51728.41 Da        Isoelectric Point: 4.9706

>NTDB_id=548936 J4Q32_RS04745 WP_233923009.1 916067..917416(+) (micB) [Streptococcus pneumoniae strain 19A-19087]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWSKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=548936 J4Q32_RS04745 WP_233923009.1 916067..917416(+) (micB) [Streptococcus pneumoniae strain 19A-19087]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGTCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.555

100

0.996
  vicK Streptococcus mutans UA159

69.652

89.532

0.624