Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   K0768_RS07260 Genome accession   NZ_CP089142
Coordinates   803186..803845 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain XD35     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 798186..808845
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K0768_RS07235 (LS330_07235) parE 798277..800169 (+) 1893 WP_001586263.1 DNA topoisomerase IV subunit B -
  K0768_RS07240 (LS330_07240) ygiN 800217..800531 (-) 315 WP_063084545.1 putative quinol monooxygenase -
  K0768_RS07245 (LS330_07245) mdaB 800562..801143 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  K0768_RS07250 (LS330_07250) ygiZ 801462..801794 (+) 333 WP_000917684.1 DUF2645 family protein -
  K0768_RS07255 (LS330_07255) qseC 801840..803189 (-) 1350 WP_063084546.1 quorum sensing histidine kinase QseC -
  K0768_RS07260 (LS330_07260) ciaR 803186..803845 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  K0768_RS07265 (LS330_07265) ygiW 803997..804389 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  K0768_RS07270 (LS330_07270) ygiV 804442..804924 (+) 483 WP_000183505.1 AraC family transcriptional regulator -
  K0768_RS07275 (LS330_07275) mqsR 805129..805425 (+) 297 WP_063084548.1 type II toxin-antitoxin system toxin MqsR -
  K0768_RS07280 (LS330_07280) mqsA 805427..805822 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  K0768_RS07285 (LS330_07285) ygiS 805955..807562 (+) 1608 WP_001295629.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=548827 K0768_RS07260 WP_001221493.1 803186..803845(-) (ciaR) [Escherichia coli strain XD35]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=548827 K0768_RS07260 WP_001221493.1 803186..803845(-) (ciaR) [Escherichia coli strain XD35]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365