Detailed information NTG0548619

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: JN057_RS06120
• Genome accession: NZ_CP071871
• Coordinates: 1202391..1203095 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain BVJ1JL
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1197391..1208095

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JN057_RS06090 (JN057_01258)	-	1197583..1198569 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
JN057_RS06095 (JN057_01259)	-	1198859..1199602 (-)	744	WP_000725952.1	potassium channel family protein	-
JN057_RS06100 (JN057_01260)	-	1199649..1199903 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE family toxin	-
JN057_RS06105 (JN057_01261)	relB	1199905..1200147 (-)	243	WP_012677101.1	type II toxin-antitoxin system RelB family antitoxin	-
JN057_RS06110 (JN057_01262)	vicX	1200238..1201047 (-)	810	WP_001289496.1	MBL fold metallo-hydrolase	Regulator
JN057_RS06115 (JN057_01263)	micB	1201049..1202398 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
JN057_RS06120 (JN057_01264)	micA	1202391..1203095 (-)	705	WP_000722076.1	response regulator YycF	Regulator
JN057_RS06125 (JN057_01265)	mutY	1203151..1204326 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
JN057_RS11590	-	1204423..1204548 (+)	126	WP_001818232.1	hypothetical protein	-
JN057_RS06130 (JN057_01266)	-	1204654..1206324 (-)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
JN057_RS06135 (JN057_01267)	coaB	1206554..1207243 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
JN057_RS06140 (JN057_01268)	coaC	1207255..1207806 (+)	552	WP_001284129.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=548619 JN057_RS06120 WP_000722076.1 1202391..1203095(-) (micA) [Streptococcus pneumoniae strain BVJ1JL]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=548619 JN057_RS06120 WP_000722076.1 1202391..1203095(-) (micA) [Streptococcus pneumoniae strain BVJ1JL]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACACGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38