NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	LKM46_RS09275	Genome accession	NZ_CP086016
Coordinates	1924203..1924874 (+)	Length	223 a.a.
NCBI ID	WP_003085524.1	Uniprot ID	A0A0H2Z6L5
Organism	Pseudomonas aeruginosa isolate KB-PA_3
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1919203..1929874

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LKM46_RS09255 (LKM46_09250)	-	1919649..1921166 (-)	1518	WP_003120784.1	tripartite tricarboxylate transporter permease	-
LKM46_RS09260 (LKM46_09255)	-	1921177..1921647 (-)	471	WP_003101933.1	tripartite tricarboxylate transporter TctB family protein	-
LKM46_RS09265 (LKM46_09260)	-	1921696..1922679 (-)	984	WP_003085519.1	tripartite tricarboxylate transporter substrate binding protein	-
LKM46_RS09270 (LKM46_09265)	-	1922709..1923992 (-)	1284	WP_033978433.1	OprD family porin	-
LKM46_RS09275 (LKM46_09270)	ciaR	1924203..1924874 (+)	672	WP_003085524.1	response regulator	Regulator
LKM46_RS09280 (LKM46_09275)	-	1924867..1926249 (+)	1383	WP_003145754.1	sensor histidine kinase	-
LKM46_RS09285 (LKM46_09280)	-	1926257..1927093 (-)	837	WP_003085528.1	HDOD domain-containing protein	-
LKM46_RS09290 (LKM46_09285)	-	1927194..1928138 (-)	945	WP_033978434.1	YgfZ/GcvT domain-containing protein	-
LKM46_RS09295 (LKM46_09290)	-	1928411..1928665 (+)	255	WP_003085532.1	succinate dehydrogenase assembly factor 2	-
LKM46_RS09300 (LKM46_09295)	-	1928649..1929101 (+)	453	WP_033978436.1	protein YgfX	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 24431.24 Da Isoelectric Point: 5.1881

                                >NTDB_id=539829 LKM46_RS09275 WP_003085524.1 1924203..1924874(+) (ciaR) [Pseudomonas aeruginosa isolate KB-PA_3]

MRILLVEDHPQLAESVVQALKGAGWTVDLLQDGVAADLALASEEYALAILDVGLPRMDGFEVLARLRGRGKTLPVLMLTA

RGEVKDRVHGLNLGADDYLAKPFELSELEARVKALLRRSVLGGEQLQRCGALVYDLGTRRFSLDEQPLTLTSREQAVLEA

MIARPGRVMSKEQLAAQVFGLDEEASADAIEIYVHRLRKKLEGGAVRIVTFRGLGYLLEAQGD

Nucleotide

Download Length: 672 bp

                                >NTDB_id=539829 LKM46_RS09275 WP_003085524.1 1924203..1924874(+) (ciaR) [Pseudomonas aeruginosa isolate KB-PA_3]

ATGCGCATCCTTCTGGTGGAAGATCATCCGCAGCTCGCCGAAAGCGTGGTCCAGGCGCTCAAGGGCGCCGGCTGGACGGT

AGACCTGCTGCAGGACGGGGTGGCCGCCGACCTGGCCCTGGCCAGCGAGGAGTACGCCCTGGCGATCCTCGACGTCGGCC

TGCCGCGGATGGACGGCTTCGAGGTGCTGGCGCGCCTGCGCGGGCGCGGCAAGACCCTGCCGGTGCTGATGCTGACTGCG

CGCGGCGAGGTGAAGGACCGGGTGCACGGCCTCAATCTCGGCGCCGACGACTACCTGGCCAAGCCTTTCGAACTGTCCGA

GCTGGAGGCGCGGGTCAAGGCCCTGCTGCGCCGCAGCGTGCTCGGCGGCGAACAGTTGCAGCGCTGCGGCGCCCTGGTCT

ACGACCTCGGCACCCGGCGCTTCAGCCTCGACGAGCAGCCGCTGACCCTGACCTCGCGGGAACAGGCGGTGCTGGAAGCG

ATGATCGCCCGTCCGGGGCGGGTGATGAGCAAGGAGCAACTGGCTGCCCAGGTCTTCGGCCTGGACGAGGAGGCCAGCGC

CGACGCCATCGAGATCTACGTCCACCGCCTACGCAAGAAGCTGGAAGGCGGCGCCGTGCGCATCGTCACCTTCCGCGGCC

TCGGCTACCTGCTGGAGGCGCAGGGTGACTGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-218)

Response regulator receiver domain (Response_reg)

(3-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0H2Z6L5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	37.668	100	0.377
ciaR	Streptococcus pneumoniae D39	37.668	100	0.377
ciaR	Streptococcus pneumoniae R6	37.668	100	0.377
ciaR	Streptococcus pneumoniae TIGR4	37.668	100	0.377
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.668	100	0.377

Detailed information NTG0539829