Detailed information NTG0053381

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: HMPREF1038_RS10280
• Genome accession: NC_018630
• Coordinates: 1901324..1902031 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166472.1
• Uniprot ID: A0A0B7LJ86
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1900211..1900675	1901324..1902031	flank	649

Gene organization within MGE regions

Location: 1900211..1902031

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS10270 (HMPREF1038_02089)	-	1900211..1900769 (-)	559	Protein_1919	transposase	-
HMPREF1038_RS10275 (HMPREF1038_02090)	-	1900755..1901240 (+)	486	WP_001845090.1	cupin domain-containing protein	-
HMPREF1038_RS10280 (HMPREF1038_02091)	vicR	1901324..1902031 (+)	708	WP_000166472.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27210.65 Da
• Isoelectric Point: 8.0403

>NTDB_id=53381 HMPREF1038_RS10280 WP_000166472.1 1901324..1902031(+) (vicR) [Streptococcus pneumoniae gamPNI0373]
MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGKQEGDDSDNIADNSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=53381 HMPREF1038_RS10280 WP_000166472.1 1901324..1902031(+) (vicR) [Streptococcus pneumoniae gamPNI0373]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTACTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAAAACAAGAAGGAGATGATTCAGATAATATCG
CTGACAATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

• Response regulator receiver domain (Response_reg) (5-115)

3D structure

• AlphaFold DB: A0A0B7LJ86

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	40.773	99.149	0.404
covR	Streptococcus salivarius strain HSISS4	39.744	99.574	0.396