Detailed information NTG0524945

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: C9Q_RS04480
• Genome accession: NZ_CP067090
• Coordinates: 875992..876828 (+)
• Length: 278 a.a.
• NCBI ID: WP_011054501.1
• Uniprot ID: A0A5S4TKN4
• Organism: Streptococcus pyogenes MGAS10870
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 870992..881828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C9Q_RS04450 (C9Q_04440)	-	871540..871914 (+)	375	WP_011054498.1	hypothetical protein	-
C9Q_RS04455 (C9Q_04445)	-	871964..872875 (-)	912	WP_002984631.1	diacylglycerol kinase family protein	-
C9Q_RS04460 (C9Q_04450)	-	872992..873642 (-)	651	WP_002984629.1	hemolysin III family protein	-
C9Q_RS04465 (C9Q_04455)	-	873639..874079 (-)	441	WP_002989774.1	DUF1836 domain-containing protein	-
C9Q_RS04470 (C9Q_04460)	ylqF	874298..875146 (+)	849	WP_011054499.1	ribosome biogenesis GTPase YlqF	-
C9Q_RS04475 (C9Q_04465)	-	875136..875927 (+)	792	WP_011054500.1	ribonuclease HII	-
C9Q_RS04480 (C9Q_04470)	dprA	875992..876828 (+)	837	WP_011054501.1	DNA-processing protein DprA	Machinery gene
C9Q_RS04485 (C9Q_04475)	topA	876934..879063 (+)	2130	WP_011054502.1	type I DNA topoisomerase	-
C9Q_RS04490 (C9Q_04480)	trmFO	879198..880544 (+)	1347	WP_032461335.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31087.14 Da
• Isoelectric Point: 9.4248

>NTDB_id=524945 C9Q_RS04480 WP_011054501.1 875992..876828(+) (dprA) [Streptococcus pyogenes MGAS10870]
MNHFELYKLKKAGLTNKNILNILDYQKHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=524945 C9Q_RS04480 WP_011054501.1 875992..876828(+) (dprA) [Streptococcus pyogenes MGAS10870]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAAA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

3D structure

• AlphaFold DB: A0A5S4TKN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.266	100	0.673
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.072	100	0.601
dprA/cilB/dalA	Streptococcus mitis SK321	60.072	100	0.601
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	59.712	100	0.597
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367