Detailed information NTG0515370

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: JAN99_RS04385
• Genome accession: NZ_CP065927
• Coordinates: 871601..872911 (+)
• Length: 436 a.a.
• NCBI ID: WP_085634321.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm9ST603
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 866601..877911

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JAN99_RS04370 (JAN99_04365)	phoU	867192..867845 (+)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-
JAN99_RS04375 (JAN99_04370)	-	868050..870587 (+)	2538	WP_014407610.1	M1 family metallopeptidase	-
JAN99_RS04380 (JAN99_04375)	ciaR	870934..871608 (+)	675	WP_002984519.1	response regulator transcription factor	Regulator
JAN99_RS04385 (JAN99_04380)	ciaH	871601..872911 (+)	1311	WP_085634321.1	HAMP domain-containing sensor histidine kinase	Regulator
JAN99_RS04390 (JAN99_04385)	rpsT	873036..873284 (-)	249	WP_009881183.1	30S ribosomal protein S20	-
JAN99_RS04395 (JAN99_04390)	coaA	873338..874258 (-)	921	WP_014407609.1	type I pantothenate kinase	-
JAN99_RS04400 (JAN99_04395)	-	874526..875119 (+)	594	WP_136116136.1	class I SAM-dependent methyltransferase	-
JAN99_RS04405 (JAN99_04400)	-	875772..876161 (+)	390	WP_011285547.1	cytidine deaminase	-
JAN99_RS04410 (JAN99_04405)	-	876255..877307 (+)	1053	WP_002989701.1	BMP family protein	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50084.61 Da
• Isoelectric Point: 9.2692

>NTDB_id=515370 JAN99_RS04385 WP_085634321.1 871601..872911(+) (ciaH) [Streptococcus pyogenes strain emm9ST603]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIAKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=515370 JAN99_RS04385 WP_085634321.1 871601..872911(+) (ciaH) [Streptococcus pyogenes strain emm9ST603]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAACTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGCGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.666	100	0.578
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516