Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrB   Type   Machinery gene
Locus tag   SIR_RS14245 Genome accession   NC_022246
Coordinates   899235..901223 (-) Length   662 a.a.
NCBI ID   WP_021002787.1    Uniprot ID   T1ZE88
Organism   Streptococcus intermedius B196     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 894235..906223
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS14215 (SIR_0878) - 894646..895272 (-) 627 WP_021002782.1 NUDIX hydrolase N-terminal domain-containing protein -
  SIR_RS14220 (SIR_0879) - 895259..895999 (-) 741 WP_003077896.1 acyl-[acyl-carrier-protein] thioesterase -
  SIR_RS14225 (SIR_0880) hemW 896003..897133 (-) 1131 WP_021002783.1 radical SAM family heme chaperone HemW -
  SIR_RS14230 (SIR_0881) - 897236..897787 (-) 552 WP_021002784.1 DUF1697 domain-containing protein -
  SIR_RS14235 (SIR_0882) - 897823..898320 (-) 498 Protein_862 N-acetyltransferase family protein -
  SIR_RS14240 (SIR_0883) - 898352..899128 (-) 777 WP_041787444.1 hypothetical protein -
  SIR_RS14245 (SIR_0884) uvrB 899235..901223 (-) 1989 WP_021002787.1 excinuclease ABC subunit UvrB Machinery gene
  SIR_RS14250 (SIR_0885) - 901839..904016 (+) 2178 WP_021002788.1 ABC transporter substrate-binding protein/permease -
  SIR_RS14255 (SIR_0886) - 904016..904756 (+) 741 WP_003072905.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 662 a.a.        Molecular weight: 75628.69 Da        Isoelectric Point: 4.5187

>NTDB_id=51102 SIR_RS14245 WP_021002787.1 899235..901223(-) (uvrB) [Streptococcus intermedius B196]
MINRITDNEFKLVSKYEPSGDQPQAIEELVDNIEGGEKAQILMGATGTGKTYTMSQVIARVNKPTLVIAHNKTLAGQLYG
EFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYS
DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGKFRVRGDVVEIFPASRDEHAFRVEFFGDEIDRIREVEALTGQVL
GEVDHLAIFPATHFMTNDENMEIAIAKIQAELVQQLAIFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDG
RSEGEPPYTLLDFFPDDFLIMIDESHMTMGQIRGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSAT
PGDYENEQTDTVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKNERTFITTLTKKMAEDLTDYFKEMGVKVKYM
HSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADT
MTQSMQRAIDETARRRAIQMAYNEEHGIVPQTIKKEIRDLISVTKAALPDKEETVEIESLNKQERKDMIKKLEGQMQEAA
GLLDFELAAQIRDMILEIKAMD

Nucleotide


Download         Length: 1989 bp        

>NTDB_id=51102 SIR_RS14245 WP_021002787.1 899235..901223(-) (uvrB) [Streptococcus intermedius B196]
ATGATAAATAGAATTACGGACAATGAATTTAAGTTGGTTTCCAAGTATGAGCCGTCAGGAGATCAACCACAGGCAATTGA
GGAATTAGTTGACAATATTGAGGGTGGAGAGAAGGCCCAGATTCTCATGGGGGCGACAGGTACTGGTAAGACCTATACCA
TGAGTCAAGTTATTGCTCGAGTTAATAAACCGACTCTGGTTATCGCCCATAATAAAACGCTGGCTGGTCAGCTTTATGGT
GAGTTCAAGGAGTTCTTTCCAAATAATGCAGTAGAATATTTTGTTTCCTACTATGATTATTACCAGCCGGAAGCCTATGT
ACCCTCTAGTGATACCTATATTGAAAAGGACAGCTCGGTCAATGACGAGATTGACAAGCTCCGTCACTCAGCGACATCAG
CCCTCTTGGAGCGTAACGATGTGATTGTCGTGGCTTCGGTCTCATGTATCTATGGTCTAGGTTCGCCTAAGGAATACTCT
GATAGCGTGGTTAGCCTACGTCCGGGTCTAGAAATTTCCCGAGATAAGCTACTCAATGATCTGGTAGATATCCAGTTTGA
GCGTAATGACATTGACTTTCAGCGGGGGAAATTCCGGGTTCGAGGCGATGTGGTGGAGATATTCCCAGCTTCTCGGGATG
AGCATGCCTTTCGGGTAGAGTTTTTTGGTGATGAGATTGACCGCATTCGAGAAGTAGAAGCGTTGACGGGACAAGTTTTG
GGTGAAGTGGATCATTTAGCAATTTTCCCTGCTACTCACTTTATGACAAATGACGAAAATATGGAAATTGCTATTGCCAA
AATTCAGGCCGAGCTGGTGCAGCAACTTGCTATCTTTGAGAAGGAAGGCAAGCTTCTGGAAGCTCAGCGCTTGAAGCAGC
GCACAGAGTATGATATCGAAATGCTGCGCGAAATGGGCTATACCAATGGTGTTGAGAACTATTCTCGCCACATGGACGGC
CGGAGCGAAGGAGAGCCACCTTATACCTTGTTGGATTTTTTCCCTGACGATTTTTTGATCATGATTGATGAGAGTCACAT
GACCATGGGACAGATTCGGGGCATGTACAATGGCGACCGCTCTCGTAAGGAGATGCTGGTTAATTATGGATTCCGCCTAC
CATCTGCCTTGGACAACCGTCCGCTGCGCCGGGAGGAGTTTGAGAGTCACGTTCATCAGATTGTCTATGTATCGGCTACA
CCGGGTGACTATGAAAATGAACAGACGGATACTGTTATTGAGCAGATTATTCGACCAACTGGGCTTCTGGATCCAGAGGT
GGAAGTTCGACCAACTATGGGGCAGATTGATGATCTTCTAGGTGAAATCAATGCTCGTGTTGAAAAGAATGAACGGACCT
TTATCACGACTTTAACCAAAAAAATGGCAGAAGACTTAACTGACTATTTCAAGGAAATGGGTGTCAAGGTCAAGTACATG
CACTCAGATATCAAGACCTTGGAGCGTACCGAGATTATCCGAGACCTGCGCTTGGGTGTTTTTGACGTTCTGGTTGGGAT
TAACCTGCTACGCGAGGGAATTGACGTGCCGGAGGTTAGTCTGGTGGCAATTCTCGATGCAGACAAGGAAGGTTTTCTCC
GCAATGAACGTGGTCTTATCCAAACCATTGGACGGGCAGCTCGCAACAGTGAAGGTCATGTGATTATGTATGCAGATACC
ATGACCCAGTCCATGCAGCGCGCTATTGATGAAACTGCCCGCCGTCGAGCAATCCAGATGGCTTACAATGAAGAGCACGG
CATTGTACCGCAGACCATCAAGAAAGAAATCCGCGACCTAATTAGCGTGACCAAGGCTGCCCTACCAGACAAGGAAGAAA
CAGTCGAAATCGAAAGCCTCAACAAGCAAGAGCGCAAGGATATGATCAAGAAACTGGAAGGCCAAATGCAAGAAGCTGCC
GGACTTCTGGACTTTGAACTGGCCGCTCAGATTCGTGATATGATATTGGAAATCAAGGCGATGGATTAA

Domains

Predicted by InterProScan.

UvrB/uvrC motif (UVR)

(626-660)

Helicase conserved C-terminal domain (Helicase_C)

(443-549)

UvrB interaction domain (UvrB_inter)

(164-254)

Type III restriction enzyme, res subunit (ResIII)

(17-143)

Ultra-violet resistance protein B (UvrB)

(556-598)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZE88

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrB Streptococcus pneumoniae R6

93.656

100

0.937
  uvrB Streptococcus pneumoniae D39

93.656

100

0.937
  uvrB Streptococcus pneumoniae TIGR4

93.505

100

0.935