Detailed information NTG0051065

Bioinformatically predicted

Overview

• Name: comD/blpH
• Type: Regulator
• Locus tag: SCR2_RS10595
• Genome accession: NC_022245
• Coordinates: 556587..557408 (-)
• Length: 273 a.a.
• NCBI ID: WP_235043796.1
• Uniprot ID: -
• Organism: Streptococcus constellatus subsp. pharyngis C818
• Function: phosphorylation of ComE; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 551587..562408

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCR2_RS02820 (SCR2_0558)	-	551917..552291 (-)	375	WP_022525583.1	hypothetical protein	-
SCR2_RS02825 (SCR2_0559)	comA/nlmT	552775..554925 (+)	2151	WP_006267089.1	peptide cleavage/export ABC transporter	Regulator
SCR2_RS02830 (SCR2_0560)	-	554936..556296 (+)	1361	Protein_545	bacteriocin secretion accessory protein	-
SCR2_RS02835 (SCR2_0561)	-	556393..556542 (+)	150	WP_003037249.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCR2_RS10595	comD/blpH	556587..557408 (-)	822	WP_235043796.1	sensor histidine kinase	Regulator
SCR2_RS02845 (SCR2_0563)	comE/blpR	557899..558645 (-)	747	WP_041786327.1	response regulator transcription factor	Regulator
SCR2_RS02850 (SCR2_0564)	-	558814..559527 (-)	714	WP_020997680.1	CPBP family intramembrane glutamic endopeptidase	-
SCR2_RS02855 (SCR2_0565)	-	559759..559980 (+)	222	WP_006267535.1	Blp family class II bacteriocin	-
SCR2_RS02865 (SCR2_0567)	-	560657..560977 (+)	321	WP_006267159.1	hypothetical protein	-
SCR2_RS02870 (SCR2_0568)	-	560985..561218 (+)	234	WP_003025420.1	garvicin Q family class II bacteriocin	-
SCR2_RS02875 (SCR2_0569)	-	561270..561560 (+)	291	WP_006267076.1	bacteriocin immunity protein	-
SCR2_RS02880 (SCR2_0570)	-	561710..562030 (+)	321	WP_006267110.1	hypothetical protein	-

Sequence

Protein

• Length: 273 a.a.
• Molecular weight: 31282.82 Da
• Isoelectric Point: 6.1166

>NTDB_id=51065 SCR2_RS10595 WP_235043796.1 556587..557408(-) (comD/blpH) [Streptococcus constellatus subsp. pharyngis C818]
MIVYHLIVQVLSYLENESNIQTLNFRESLVVLYLILFVSVANYLDRHLRERIQNDLMLQKDLQLKNMENYSHHIEELYTE
VRSFRHDYANILTTLKLGIEQNDIGIVKNVYHSVLKDSNKRFRNPKYDIGRLVHIKNDALKSLLAAKFAQAQEHNVSVSL
EVPEDICPQGMELIDFITIVSILCDNAIEATTPTMTIAYVLSENKQVFSIENAIKEEHIDMSYIFDAGVSSKGSGRGIGL
SNVLAILDRYPNVSLTSASQNYRFQHVLEIHLN

Nucleotide

• Length: 822 bp

>NTDB_id=51065 SCR2_RS10595 WP_235043796.1 556587..557408(-) (comD/blpH) [Streptococcus constellatus subsp. pharyngis C818]
ATGATTGTTTATCATCTTATTGTTCAAGTTCTATCTTATTTAGAAAACGAGAGTAACATACAGACACTAAATTTTAGAGA
AAGTTTAGTAGTTCTTTATCTTATCCTTTTTGTGAGTGTTGCCAATTATTTAGACCGTCATTTACGAGAGAGAATCCAAA
ATGATTTAATGCTTCAAAAAGATTTACAGTTAAAAAATATGGAAAACTACAGTCATCACATTGAGGAATTGTACACAGAA
GTTCGGAGCTTTCGGCATGATTACGCTAATATTTTAACAACCTTGAAATTAGGAATTGAGCAAAATGATATAGGCATTGT
AAAGAATGTCTATCATTCTGTTTTGAAAGATTCCAATAAGCGTTTTCGCAATCCCAAGTATGATATTGGACGGTTAGTCC
ATATCAAAAACGATGCCTTAAAAAGCCTGCTAGCTGCTAAATTTGCACAAGCTCAAGAGCATAATGTATCCGTTTCATTG
GAGGTTCCAGAAGATATTTGTCCACAAGGAATGGAATTAATTGACTTTATCACCATTGTCTCCATTTTGTGTGATAATGC
GATTGAAGCTACCACTCCAACTATGACGATTGCTTATGTTTTGTCAGAAAACAAGCAGGTATTCTCCATTGAAAATGCTA
TAAAAGAAGAGCATATAGACATGTCTTATATTTTTGATGCGGGAGTTAGTTCTAAAGGATCTGGGCGAGGAATTGGATTA
TCAAATGTCTTAGCAATTCTGGATCGATATCCAAATGTTTCTCTTACTAGCGCTAGTCAAAATTATCGTTTCCAGCATGT
CCTTGAGATTCATCTGAATTAA

Domains

Predicted by InterProScan.

• GHKL domain (HATPase_c_5) (171-266)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/blpH	Streptococcus mutans UA159	43.796	100	0.44
comD/comD3	Streptococcus equinus JB1	41.107	92.674	0.381
comD/comD2	Streptococcus equinus JB1	37.681	100	0.381