Detailed information NTG0051044

Bioinformatically predicted

Overview

• Name: comGH
• Type: Machinery gene
• Locus tag: SCR2_RS08560
• Genome accession: NC_022245
• Coordinates: 1729641..1730594 (-)
• Length: 317 a.a.
• NCBI ID: WP_020998065.1
• Uniprot ID: U2XY22
• Organism: Streptococcus constellatus subsp. pharyngis C818
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1724641..1735594

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCR2_RS08550 (SCR2_1680)	glmS	1726190..1728004 (-)	1815	WP_020998064.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
SCR2_RS08555 (SCR2_1681)	-	1728395..1729594 (-)	1200	WP_006267970.1	acetate kinase	-
SCR2_RS08560 (SCR2_1682)	comGH	1729641..1730594 (-)	954	WP_020998065.1	class I SAM-dependent methyltransferase	Machinery gene
SCR2_RS08565 (SCR2_1683)	comGG/cglG	1730679..1731005 (-)	327	WP_020998066.1	competence type IV pilus minor pilin ComGG	Machinery gene
SCR2_RS08570 (SCR2_1684)	comGF/cglF	1730986..1731423 (-)	438	WP_003035329.1	competence type IV pilus minor pilin ComGF	Machinery gene
SCR2_RS08575 (SCR2_1685)	comGE/cglE	1731407..1731700 (-)	294	WP_003035318.1	competence type IV pilus minor pilin ComGE	Machinery gene
SCR2_RS08580 (SCR2_1686)	comGD	1731672..1732100 (-)	429	WP_020999411.1	competence type IV pilus minor pilin ComGD	Machinery gene
SCR2_RS08585 (SCR2_1687)	comGC	1732060..1732377 (-)	318	WP_020998068.1	competence type IV pilus major pilin ComGC	Machinery gene
SCR2_RS08590 (SCR2_1688)	comGB	1732374..1733396 (-)	1023	WP_037592679.1	competence type IV pilus assembly protein ComGB	Machinery gene
SCR2_RS08595 (SCR2_1689)	comGA	1733338..1734279 (-)	942	WP_006268058.1	competence type IV pilus ATPase ComGA	Machinery gene
SCR2_RS08600	-	1734349..1734714 (-)	366	WP_022525692.1	DUF1033 family protein	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 35934.56 Da
• Isoelectric Point: 4.2141

>NTDB_id=51044 SCR2_RS08560 WP_020998065.1 1729641..1730594(-) (comGH) [Streptococcus constellatus subsp. pharyngis C818]
MNFEKIEQAYSLLLENVQELQNTLLTNFYDALVEQNGVYLDGNTELDIVKKNNETLKSLKLDKEEWRRAYQFLLMKAAQT
EPLQANHQFTPDSIGFIVTFLIDQLSNKEHIDVLEIGSGMGNLAETILNNTNKNVDYLGLELDDLLIDISASIADVMDAK
VSFVQGDAVRPQVLKESDVIISDLPVGFYPDDNIATRYEVASRQEHTYAHHLLMEQSLKYLKSDGYAIFLAPNDLLTSTQ
SDLLKNWLQNHAQIVAMIALPESLFGNAAYAKTIFVLKKQDEQAVQPFVYALSDLQNQADLLTFSEKFQNWSQESEI

Nucleotide

• Length: 954 bp

>NTDB_id=51044 SCR2_RS08560 WP_020998065.1 1729641..1730594(-) (comGH) [Streptococcus constellatus subsp. pharyngis C818]
ATGAATTTTGAAAAAATAGAACAGGCTTATTCGCTTTTGTTAGAAAATGTCCAGGAGCTCCAAAATACTCTTTTGACGAA
TTTTTATGATGCTTTGGTCGAGCAAAATGGGGTTTATCTGGATGGAAATACAGAGCTAGATATTGTCAAAAAAAATAATG
AAACACTTAAATCTTTGAAATTAGATAAAGAAGAATGGCGACGAGCATACCAATTTTTGCTGATGAAAGCGGCTCAAACA
GAGCCTTTGCAAGCTAATCATCAATTTACTCCGGATTCTATTGGTTTTATCGTAACATTTCTCATTGACCAATTGAGTAA
TAAAGAACATATTGATGTGTTGGAAATTGGTAGTGGAATGGGAAATTTGGCAGAAACCATTCTTAATAATACAAATAAAA
ACGTGGATTATCTAGGGCTGGAATTGGACGATCTGCTAATTGATATATCAGCCAGTATCGCAGATGTGATGGATGCAAAA
GTTAGTTTTGTGCAAGGTGATGCGGTGCGCCCGCAAGTATTGAAAGAAAGCGATGTGATTATCAGTGATTTACCAGTTGG
CTTTTATCCTGATGATAACATTGCGACGCGCTATGAAGTGGCTAGTAGACAGGAGCATACTTATGCTCATCATTTGTTAA
TGGAACAATCGCTCAAGTATCTCAAATCGGATGGTTATGCTATTTTCCTTGCACCAAATGATTTACTGACTAGCACACAA
AGTGATTTATTAAAAAATTGGTTGCAGAATCATGCACAAATAGTTGCAATGATTGCGTTACCAGAGTCTCTTTTTGGAAA
TGCAGCATACGCTAAAACAATTTTTGTACTGAAAAAGCAAGATGAACAAGCTGTCCAACCATTTGTTTATGCTTTATCTG
ATTTGCAGAATCAAGCGGATTTATTGACATTTAGCGAAAAGTTTCAAAATTGGAGCCAAGAAAGTGAAATTTAA

Domains

Predicted by InterProScan.

• N-6 DNA Methylase (N6_Mtase) (68-294)

3D structure

• AlphaFold DB: U2XY22

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGH	Streptococcus mutans UA140	61.587	99.369	0.612
comGH	Streptococcus mutans UA159	61.27	99.369	0.609