Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ST90729_RS03535 Genome accession   NZ_CP065480
Coordinates   660944..661684 (+) Length   246 a.a.
NCBI ID   WP_096811959.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain 90729     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 657474..677002 660944..661684 within 0


Gene organization within MGE regions


Location: 657474..677002
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST90729_RS03510 (ST90729_03490) - 657474..657836 (+) 363 WP_065973038.1 SAG1252 family conjugative relaxosome accessory protein -
  ST90729_RS03515 (ST90729_03495) mobC 657839..658204 (+) 366 WP_039671039.1 plasmid mobilization relaxosome protein MobC -
  ST90729_RS03520 (ST90729_03500) - 658191..660074 (+) 1884 WP_173940477.1 SAG1250 family conjugative relaxase -
  ST90729_RS03525 - 660007..660402 (-) 396 WP_232085807.1 hypothetical protein -
  ST90729_RS03530 (ST90729_03510) - 660601..660942 (+) 342 WP_024404826.1 LytTR family DNA-binding domain-containing protein -
  ST90729_RS03535 (ST90729_03515) comE/blpR 660944..661684 (+) 741 WP_096811959.1 response regulator transcription factor Regulator
  ST90729_RS03540 (ST90729_03520) - 661695..663035 (+) 1341 WP_039671036.1 GHKL domain-containing protein -
  ST90729_RS03545 (ST90729_03525) - 663083..663238 (-) 156 WP_096811960.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  ST90729_RS03550 (ST90729_03530) - 663337..664698 (-) 1362 WP_096811961.1 bacteriocin secretion accessory protein -
  ST90729_RS03555 (ST90729_03535) comA/nlmT 664710..666863 (-) 2154 WP_024404830.1 peptide cleavage/export ABC transporter Regulator
  ST90729_RS03560 (ST90729_03540) - 667161..667418 (+) 258 WP_039671027.1 Blp family class II bacteriocin -
  ST90729_RS03565 (ST90729_03545) - 667435..667629 (+) 195 WP_039671026.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ST90729_RS03570 (ST90729_03550) - 668232..669583 (+) 1352 WP_096811962.1 IS3 family transposase -
  ST90729_RS03575 (ST90729_03555) - 670004..671035 (+) 1032 WP_065973046.1 thioredoxin fold domain-containing protein -
  ST90729_RS03580 (ST90729_03560) - 671039..671734 (+) 696 WP_065973047.1 type II CAAX endopeptidase family protein -
  ST90729_RS03585 (ST90729_03565) - 671764..671916 (+) 153 WP_155758745.1 hypothetical protein -
  ST90729_RS03590 (ST90729_03570) - 672102..672497 (+) 396 WP_065973048.1 hypothetical protein -
  ST90729_RS03595 (ST90729_03575) - 673004..674797 (+) 1794 WP_176243450.1 recombinase family protein -
  ST90729_RS03600 (ST90729_03580) - 675002..675832 (+) 831 WP_176243466.1 GIY-YIG nuclease family protein -
  ST90729_RS03605 (ST90729_03585) - 676000..676221 (+) 222 WP_176243451.1 helix-turn-helix domain-containing protein -
  ST90729_RS03610 (ST90729_03590) - 676218..676625 (+) 408 WP_232970703.1 DNA adenine methylase -
  ST90729_RS03615 (ST90729_03595) - 676847..677002 (-) 156 WP_176243452.1 hypothetical protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28894.15 Da        Isoelectric Point: 7.2201

>NTDB_id=510184 ST90729_RS03535 WP_096811959.1 660944..661684(+) (comE/blpR) [Streptococcus thermophilus strain 90729]
MNIFVMEDDFMQQARIEKIITKLLEKHNIVPKKFEISGKPHQLLQAIEEKGVHQLFFLDIEIKEDELKGLQVAKQIREID
PYASIVFVTTHSEFMPLSFRYQVSALDYIDKELGVTEFESRIEAALLHTHNKDNSAVSDDSFYFKSKYAQVQYPFNEVYY
IETSPRPHRVILYTKTDRMEFTASLSDILKQDKRLVQCHRSFAINPRNVVKVDRNEKQIYFPNGATCFISRQKLESTLAV
IDRLHR

Nucleotide


Download         Length: 741 bp        

>NTDB_id=510184 ST90729_RS03535 WP_096811959.1 660944..661684(+) (comE/blpR) [Streptococcus thermophilus strain 90729]
ATGAATATCTTTGTAATGGAAGATGATTTTATGCAACAAGCGAGAATTGAGAAGATTATTACTAAGCTGTTAGAAAAGCA
CAACATCGTTCCGAAAAAATTTGAAATTTCAGGAAAACCTCATCAGCTACTTCAAGCAATAGAAGAAAAAGGAGTACATC
AGCTCTTCTTTTTAGATATTGAGATTAAGGAAGACGAACTAAAAGGACTTCAAGTCGCTAAACAAATTAGAGAGATTGAC
CCTTATGCTAGTATTGTTTTTGTGACAACACACTCCGAGTTTATGCCCTTATCTTTCAGGTACCAGGTATCTGCCTTGGA
CTATATTGACAAAGAGCTTGGAGTTACCGAATTTGAATCGCGAATAGAAGCAGCTTTACTTCATACTCACAATAAGGACA
ATAGCGCCGTATCGGATGATTCATTCTATTTTAAGTCCAAATATGCTCAAGTACAATACCCATTCAATGAAGTGTACTAC
ATCGAGACTTCTCCCCGCCCTCATCGTGTTATCCTTTATACCAAGACAGACCGAATGGAGTTCACAGCAAGTTTGTCAGA
CATTTTGAAACAAGATAAACGACTTGTACAATGTCATCGTTCGTTTGCAATCAATCCGAGGAATGTTGTTAAAGTGGATA
GAAATGAAAAACAGATCTACTTTCCTAATGGAGCCACCTGTTTTATTTCAAGGCAAAAGCTAGAATCAACTTTAGCTGTT
ATTGATAGACTGCATAGATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.719

98.374

0.528
  comE/comE1 Streptococcus equinus JB1

41.423

97.154

0.402
  comE/comE2 Streptococcus equinus JB1

36.475

99.187

0.362