Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   ST4052_RS05220 Genome accession   NZ_CP065476
Coordinates   996572..997912 (-) Length   446 a.a.
NCBI ID   WP_011227273.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain 4052     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 991572..1002912
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4052_RS05190 (ST4052_05275) - 991690..992076 (-) 387 WP_002953113.1 DUF1934 domain-containing protein -
  ST4052_RS05195 (ST4052_05280) - 992134..993048 (-) 915 Protein_967 GNAT family N-acetyltransferase -
  ST4052_RS05200 (ST4052_05285) yidA 993256..994065 (+) 810 WP_011226081.1 sugar-phosphatase -
  ST4052_RS05205 (ST4052_05290) - 994067..995281 (+) 1215 WP_011227270.1 aminoacyltransferase -
  ST4052_RS05210 (ST4052_05295) - 995333..995694 (-) 362 Protein_970 YbaN family protein -
  ST4052_RS05215 (ST4052_05300) vicX 995754..996566 (-) 813 WP_011681204.1 MBL fold metallo-hydrolase Regulator
  ST4052_RS05220 (ST4052_05305) vicK 996572..997912 (-) 1341 WP_011227273.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ST4052_RS05225 (ST4052_05310) vicR 997905..998612 (-) 708 WP_011227274.1 response regulator YycF Regulator
  ST4052_RS05230 (ST4052_05315) - 999143..999910 (+) 768 WP_347100829.1 amino acid ABC transporter ATP-binding protein -
  ST4052_RS05235 (ST4052_05320) - 999922..1000755 (+) 834 WP_011227276.1 transporter substrate-binding domain-containing protein -
  ST4052_RS05240 (ST4052_05325) - 1000773..1001471 (+) 699 WP_011226087.1 amino acid ABC transporter permease -
  ST4052_RS05245 (ST4052_05330) - 1001483..1002133 (+) 651 WP_011226088.1 amino acid ABC transporter permease -

Sequence

Protein


Download         Length: 446 a.a.        Molecular weight: 50768.12 Da        Isoelectric Point: 5.2464

>NTDB_id=509950 ST4052_RS05220 WP_011227273.1 996572..997912(-) (vicK) [Streptococcus thermophilus strain 4052]
MTSIGLNITSFELALLFMLLFVAFYFIFLAYRDYQQVKNIRKLTKRVKSLMAGNYNEKLCIKGDSELLELANSLNDLSDV
FRLTHENLIQEKNRLSSVLSYMSDGVIATNRLGQITMINSTAQRLLNLDRETATQMSILDILDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALNE
EIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLNVEMTNFTAFMTYILNRFGQIKSQETNPGKSYEIIRDYPVNSI
WVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIVKQHNGFIWAKSEYGKGSTFTIVLPYDQDAMMVDEWEM

Nucleotide


Download         Length: 1341 bp        

>NTDB_id=509950 ST4052_RS05220 WP_011227273.1 996572..997912(-) (vicK) [Streptococcus thermophilus strain 4052]
ATGACTAGTATTGGCTTAAATATTACAAGCTTTGAACTGGCCTTACTCTTTATGCTCCTCTTTGTTGCTTTCTATTTCAT
TTTTCTAGCTTATCGTGATTATCAACAGGTCAAAAATATCCGAAAGTTGACTAAGAGAGTCAAATCCCTTATGGCAGGTA
ATTATAATGAAAAATTATGCATAAAGGGAGATTCAGAGCTTTTAGAGCTAGCTAATAGCTTGAATGATTTGTCGGACGTC
TTTCGTTTGACACATGAAAATCTAATCCAGGAAAAAAACCGCTTATCATCTGTTCTTTCGTACATGAGTGACGGGGTTAT
TGCGACCAATCGCCTTGGTCAGATTACTATGATTAATAGTACTGCCCAACGCTTATTGAATTTAGATCGCGAAACTGCGA
CTCAGATGTCTATTTTGGATATATTAGATGGTGAGAATCCCTATACCTATAGTGAATTGTTGTCTAAGACACCCGAAATC
CATCTGTCGCGTCGAGATGCTAACGATGAATTTGTGACGCTACGTGTTAATTTTGCATTAATTCGTAAGGAATCTGGTTT
TATTTCAGGTCTGGTAGCCGTTCTTCATGATGCCACTGAGCAGGAAAAAGAAGAGCGCGAACGCCGTCTCTTCGTATCAA
ATGTTAGTCACGAATTGCGGACGCCTTTAACTTCTGTGAAATCCTATCTTGAAGCGCTTGATGATGGTGCTCTCAACGAA
GAGATTGCTCCAAACTTTATCAAAGTTTCTTTAGATGAAACCAACCGCATGATGCGTATGATTTCTGACCTCTTGGCATT
ATCTCGAATTGACAATAAAAGCACACAGCTTAATGTTGAAATGACAAACTTTACAGCCTTTATGACCTATATCTTGAATC
GGTTTGGTCAAATTAAGAGTCAAGAAACTAATCCAGGTAAGTCTTATGAAATCATTCGAGATTACCCAGTAAACTCTATT
TGGGTGGAAATTGATACTGATAAGATGACCCAGGTCATAGATAATATACTTAATAATGCCATCAAGTATTCTCCTGATGG
TGGGAAAATTACAGTATCTATGAAAACGACAGACACTCAGTTGATTGTTTCTATTTCTGACCAAGGTTTAGGAATTCCTA
AAAAAGATTTACCTCTGATTTTTGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCTCAGGGTGGAACAGGACTT
GGCTTGTCCATTGCAAAAGAAATTGTTAAACAACATAATGGCTTCATTTGGGCTAAGAGTGAGTATGGTAAGGGATCAAC
TTTTACAATTGTGCTTCCATATGACCAGGACGCAATGATGGTCGATGAATGGGAGATGTAG

Domains

Predicted by InterproScan.

HAMP domain (HAMP)

(37-79)

PAS fold (PAS)

(94-197)

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

74.396

92.825

0.691
  micB Streptococcus pneumoniae Cp1015

66.051

97.085

0.641