Detailed information NTG0050971

Bioinformatically predicted

Overview

• Name: pilC
• Type: Machinery gene
• Locus tag: D7S_RS07995
• Genome accession: NC_017846
• Coordinates: 1610088..1611311 (-)
• Length: 407 a.a.
• NCBI ID: WP_005540455.1
• Uniprot ID: Q8KRY4
• Organism: Aggregatibacter actinomycetemcomitans D7S-1
• Function: type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1605088..1616311

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D7S_RS07975 (D7S_01716)	-	1605751..1607871 (-)	2121	WP_005539198.1	alpha/beta hydrolase	-
D7S_RS07980 (D7S_03395)	-	1607894..1608781 (-)	888	WP_014702484.1	DUF4123 domain-containing protein	-
D7S_RS07985	-	1609056..1609226 (-)	171	WP_014702486.1	hypothetical protein	-
D7S_RS07990 (D7S_01720)	-	1609402..1610091 (-)	690	WP_005594882.1	prepilin peptidase	-
D7S_RS07995 (D7S_01721)	pilC	1610088..1611311 (-)	1224	WP_005540455.1	type II secretion system F family protein	Machinery gene
D7S_RS08000 (D7S_01722)	pilB	1611304..1612713 (-)	1410	WP_005540457.1	GspE/PulE family protein	Machinery gene
D7S_RS08005 (D7S_01723)	pilA	1612740..1613192 (-)	453	WP_005550263.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	Machinery gene
D7S_RS08010 (D7S_01724)	ampD	1613314..1613868 (+)	555	WP_005540460.1	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	-
D7S_RS08015 (D7S_01726)	nanQ	1614334..1614807 (-)	474	WP_005594879.1	N-acetylneuraminate anomerase	-

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 46222.71 Da
• Isoelectric Point: 10.3517

>NTDB_id=50971 D7S_RS07995 WP_005540455.1 1610088..1611311(-) (pilC) [Aggregatibacter actinomycetemcomitans D7S-1]
MTKLKLFQWRGVNRLQQKQKGLIVAETEVMAQQQLLSRGLQNIKLQQNWQFSHKPKNADICTLLSQLATLLRAAVPLKNS
LQILLQNCTNIALNRWLRCLLQEIESGLAFSQALEQQGLYLTYQERQLIQVGEMTGKLAAVCHEIAQHKQQALALQRKIQ
KILLYPLLVLGISLILTALLLLFIVPQFAAMYDNSNAQLPVFTQVLLALSQGLQDYWFALLMFIALTVALIRFRLKHSPW
LNRQKNRLINSIPLLNRIVQLSRLVGFSRSLFLMLQAGIPLNQALQSFLPKQQSWQSKPQQQGDWLLITEVQSALHWIQQ
GYPFSASVSGQIFPPAAQQMLQVGEQSGQLPKMLQFIANDHQQQLDHQIDLLSQMLEPLLMVIIGGLIGLIMLGMYLPIF
NMGSLVQ

Nucleotide

• Length: 1224 bp

>NTDB_id=50971 D7S_RS07995 WP_005540455.1 1610088..1611311(-) (pilC) [Aggregatibacter actinomycetemcomitans D7S-1]
ATGACTAAATTGAAACTGTTTCAATGGCGCGGCGTTAATCGCTTGCAGCAAAAACAAAAAGGCTTAATCGTGGCGGAAAC
GGAGGTGATGGCACAACAACAGCTGCTTTCACGTGGGTTGCAAAACATCAAATTGCAACAAAACTGGCAATTCAGCCACA
AACCGAAAAATGCCGACATCTGCACCCTGCTTTCCCAACTGGCGACGCTATTACGAGCCGCCGTGCCGCTGAAAAACAGC
CTGCAAATTTTATTGCAAAATTGTACCAATATTGCGTTGAATCGCTGGCTACGCTGCTTGCTACAGGAGATTGAAAGCGG
CTTGGCATTTTCTCAAGCATTGGAACAACAAGGGTTATACTTAACCTATCAGGAACGCCAACTGATTCAGGTGGGTGAAA
TGACAGGCAAACTTGCCGCCGTCTGTCATGAAATCGCACAACATAAACAACAGGCGCTGGCGTTGCAGCGTAAAATTCAG
AAAATCCTGCTTTATCCGTTGCTGGTGCTCGGAATCTCATTGATTTTGACCGCACTTTTATTGCTGTTCATCGTGCCGCA
ATTTGCCGCCATGTATGACAACAGCAACGCGCAACTGCCCGTGTTCACGCAGGTTTTACTAGCCCTTTCCCAAGGCTTGC
AGGATTATTGGTTCGCGCTACTCATGTTTATTGCGCTGACCGTGGCGTTAATTCGCTTTCGCCTCAAACATTCGCCTTGG
CTTAACCGACAAAAAAACCGGCTGATTAACAGTATTCCGTTGCTTAATCGTATCGTACAACTCTCCCGCCTGGTGGGATT
CAGTCGCAGCTTGTTTTTGATGTTACAGGCAGGTATTCCGCTGAATCAGGCGCTGCAATCTTTTCTACCGAAGCAACAAA
GCTGGCAAAGCAAACCGCAACAGCAAGGGGATTGGCTATTAATTACAGAAGTGCAATCGGCACTGCATTGGATTCAACAA
GGCTATCCGTTCTCCGCCAGCGTAAGCGGACAAATCTTCCCGCCGGCGGCACAGCAAATGCTGCAAGTCGGCGAACAAAG
CGGTCAATTGCCGAAAATGCTGCAATTTATCGCCAACGATCATCAGCAACAGTTGGATCACCAAATCGATCTGCTGTCAC
AAATGCTGGAACCGTTGTTGATGGTGATTATCGGCGGGCTGATCGGCTTGATTATGCTCGGTATGTATTTACCGATTTTC
AACATGGGCTCGCTGGTGCAATGA

Domains

Predicted by InterproScan.

• Type II secretion system (T2SS), protein F (T2SSF) (267-398)

• Type II secretion system (T2SS), protein F (T2SSF) (64-186)

3D structure

• AlphaFold DB: Q8KRY4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilC	Haemophilus influenzae Rd KW20	63.145	100	0.631
pilC	Haemophilus influenzae 86-028NP	62.899	100	0.629
pilC	Glaesserella parasuis strain SC1401	39.066	100	0.391