NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	I2437_RS04945	Genome accession	NZ_CP065061
Coordinates	1014685..1015422 (-)	Length	245 a.a.
NCBI ID	WP_012515591.1	Uniprot ID	B4U2V5
Organism	Streptococcus equi subsp. zooepidemicus strain SEZ33
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1009685..1020422

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2437_RS04925 (IEMOCGPF_00985)	ylqF	1009821..1010675 (-)	855	WP_165627826.1	ribosome biogenesis GTPase YlqF	-
I2437_RS04930 (IEMOCGPF_00986)	-	1011267..1011881 (-)	615	WP_231185769.1	putative bacteriocin export ABC transporter	-
I2437_RS04935 (IEMOCGPF_00987)	-	1011901..1013916 (-)	2016	WP_111710561.1	DUF1430 domain-containing protein	-
I2437_RS04940 (IEMOCGPF_00988)	-	1014112..1014312 (-)	201	WP_012515592.1	hypothetical protein	-
I2437_RS04945 (IEMOCGPF_00989)	comE/blpR	1014685..1015422 (-)	738	WP_012515591.1	response regulator transcription factor	Regulator
I2437_RS04950 (IEMOCGPF_00990)	-	1016195..1016500 (-)	306	WP_012677981.1	AraC family ligand binding domain-containing protein	-
I2437_RS04955 (IEMOCGPF_00991)	-	1016502..1016840 (-)	339	WP_014622843.1	cupin domain-containing protein	-
I2437_RS04960 (IEMOCGPF_00992)	-	1016868..1017623 (-)	756	WP_042670619.1	class I SAM-dependent methyltransferase	-
I2437_RS04965 (IEMOCGPF_00993)	-	1017883..1018338 (+)	456	WP_014622841.1	DUF1836 domain-containing protein	-
I2437_RS04970 (IEMOCGPF_00994)	-	1018322..1018972 (+)	651	WP_042670617.1	hemolysin III family protein	-
I2437_RS04975 (IEMOCGPF_00995)	-	1019082..1019987 (+)	906	WP_012677986.1	diacylglycerol kinase family protein	-

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28894.28 Da Isoelectric Point: 7.8796

                                >NTDB_id=506606 I2437_RS04945 WP_012515591.1 1014685..1015422(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain SEZ33]

MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDSQIRNDEKKGLAVAREIRKRD

PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFVTAKAQVQVPFSSLLF

IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS

IKALH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=506606 I2437_RS04945 WP_012515591.1 1014685..1015422(-) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain SEZ33]

ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA

TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC

AGCTTTTCTTTCTCGATAGTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC

CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA

TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG

AAAATGTAACCTCAGAGGGCTTATTTATTTTTGTAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC

ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA

GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC

GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT

ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-240)

Response regulator receiver domain (Response_reg)

(18-122)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	B4U2V5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	53.719	98.776	0.531
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	36.885	99.592	0.367

Detailed information NTG0506606