Detailed information NTG0506424

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: I2434_RS04780
• Genome accession: NZ_CP065058
• Coordinates: 1015595..1016332 (+)
• Length: 245 a.a.
• NCBI ID: WP_165623379.1
• Uniprot ID: -
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ18
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1010595..1021332

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2434_RS04750 (MCPGFBBE_00943)	-	1011037..1011942 (-)	906	WP_165623378.1	diacylglycerol kinase family protein	-
I2434_RS04755 (MCPGFBBE_00944)	-	1012052..1012702 (-)	651	WP_012515586.1	hemolysin III family protein	-
I2434_RS04760 (MCPGFBBE_00945)	-	1012686..1013141 (-)	456	WP_043983552.1	DUF1836 domain-containing protein	-
I2434_RS04765 (MCPGFBBE_00946)	-	1013401..1014156 (+)	756	WP_206157683.1	class I SAM-dependent methyltransferase	-
I2434_RS04770 (MCPGFBBE_00947)	-	1014184..1014522 (+)	339	WP_021320756.1	cupin domain-containing protein	-
I2434_RS04775 (MCPGFBBE_00948)	-	1014524..1014829 (+)	306	WP_021320757.1	AraC family ligand binding domain-containing protein	-
I2434_RS04780 (MCPGFBBE_00949)	comE/blpR	1015595..1016332 (+)	738	WP_165623379.1	response regulator transcription factor	Regulator
I2434_RS04785 (MCPGFBBE_00950)	-	1016705..1016905 (+)	201	WP_042670621.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
I2434_RS04790 (MCPGFBBE_00951)	-	1016972..1017826 (+)	855	WP_165623388.1	ABC transporter ATP-binding protein	-
I2434_RS04795 (MCPGFBBE_00952)	-	1017832..1018995 (+)	1164	WP_042670623.1	ABC transporter permease subunit	-
I2434_RS04800 (MCPGFBBE_00953)	-	1019257..1019487 (+)	231	WP_012515596.1	Blp family class II bacteriocin	-
I2434_RS04805 (MCPGFBBE_00954)	-	1020363..1020644 (+)	282	WP_012515598.1	lactococcin 972 family bacteriocin	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28935.34 Da
• Isoelectric Point: 8.2668

>NTDB_id=506424 I2434_RS04780 WP_165623379.1 1015595..1016332(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain SEZ18]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDIQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIRYAYEEQENVTSEGLFIFATAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=506424 I2434_RS04780 WP_165623379.1 1015595..1016332(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain SEZ18]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACGTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATATTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCTCTCATTGTTTTTGTCACGACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATCGATAAGGAATTATCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTAGGTATGCTTATGAAGAACAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGCAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTT
ATTGAGACCTCTAGTACCCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.132	98.776	0.535
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	37.295	99.592	0.371